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A clinical gamma camera-based pinhole collimated system for high resolution small animal SPECT imaging BJMBR
Mejia,J.; Galvis-Alonso,O.Y.; Castro,A.A.de; Braga,J.; Leite,J.P.; Simões,M.V..
The main objective of the present study was to upgrade a clinical gamma camera to obtain high resolution tomographic images of small animal organs. The system is based on a clinical gamma camera to which we have adapted a special-purpose pinhole collimator and a device for positioning and rotating the target based on a computer-controlled step motor. We developed a software tool to reconstruct the target’s three-dimensional distribution of emission from a set of planar projections, based on the maximum likelihood algorithm. We present details on the hardware and software implementation. We imaged phantoms and heart and kidneys of rats. When using pinhole collimators, the spatial resolution and sensitivity of the imaging system depend on parameters such as...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pinhole collimator; SPECT; Small animal organs; Maximum likelihood; Instrumentation; Image processing.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200004
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Methodological approaches to planar and volumetric scintigraphic imaging of small volume targets with high spatial resolution and sensitivity BJMBR
Mejia,J.; Galvis-Alonso,O.Y.; Braga,J.; Corrêa,R.; Leite,J.P.; Simões,M.V..
Single-photon emission computed tomography (SPECT) is a non-invasive imaging technique, which provides information reporting the functional states of tissues. SPECT imaging has been used as a diagnostic tool in several human disorders and can be used in animal models of diseases for physiopathological, genomic and drug discovery studies. However, most of the experimental models used in research involve rodents, which are at least one order of magnitude smaller in linear dimensions than man. Consequently, images of targets obtained with conventional gamma-cameras and collimators have poor spatial resolution and statistical quality. We review the methodological approaches developed in recent years in order to obtain images of small targets with good spatial...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Small animal SPECT; Multipinhole collimators; Coded masks.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000800001
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