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	Provedor de dados BJM (1) Autor Brandão,Paulo (1) Ono,Ekaterina Alexandrovna Durymanova (1) Taniwaki,Sueli Akemi (1) Palavra-chave RNA interference (1) Rabies (1) Treatment (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Short interfering RNAs targeting a vampire-bat related rabies virus phosphoprotein mRNA BJM Ono,Ekaterina Alexandrovna Durymanova; Taniwaki,Sueli Akemi; Brandão,Paulo. Abstract The aim of this study was to assess the in vitro and in vivo effects of short-interfering RNAs (siRNAs) against rabies virus phosphoprotein (P) mRNA in a post-infection treatment for rabies as an extension of a previous report (Braz J Microbiol. 2013 Nov 15;44(3):879-82). To this end, rabies virus strain RABV-4005 (related to the Desmodus rotundus vampire bat) were used to inoculate BHK-21 cells and mice, and the transfection with each of the siRNAs was made with Lipofectamine-2000™. In vitro results showed that siRNA 360 was able to inhibit the replication of strain RABV-4005 with a 1 log decrease in virus titter and 5.16-fold reduction in P mRNA, 24 h post-inoculation when compared to non-treated cells. In vivo, siRNA 360 was able to induce... Tipo: Info:eu-repo/semantics/article Palavras-chave: Rabies; Treatment; RNA interference. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000300566 Registros recuperados: 1 Primeira ... 1 ... Última

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