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	Provedor de dados BJMBR (4) Autor Brasileiro-Filho,G. (4) Boson,W.L.M. (1) Caballero,O.L. (1) Costa,M.C.S.L. (1) De Marco,L.A. (1) Fuzikawa,A.K. (1) Haddad,L.A. (1) Oliveira,R.M. (1) Pena,S.D.J. (1) Penna,F.J. (1) Péret-Filho,L.A. (1) Reis,F.J.C. (1) Sabagga,E. (1) Simpson,A.J.G. (1) Trevisan,A. (1) Távora,E.R.F. (1) Távora,P.F. (1) Vidigal,P.V.T. (1) Vilaça,S.S. (1) Villa,L.L. (1) Mais... Palavra-chave Polymerase chain reaction (2) Biopsy (1) Colorectal carcinoma (1) Cystic fibrosis (1) Cystic fibrosis transmembrane conductance regulator (1) DCC (1) Diagnosis (1) Human cytomegalovirus (1) Jejunal mucosa (1) Microsatellite (1) Microsatellite instability (1) P.F508del (1) P53 (1) Protracted diarrhea (1) Renal transplant (1) Serum albumin (1) Viral load (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Info:eu-repo/semantics/other (1) Ano 2008 (1) 1999 (1) 1997 (2) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Utilization of microsatellites for the analysis of genomic alterations in colorectal cancers in Brazil BJMBR Fuzikawa,A.K.; Haddad,L.A.; da-Cunha-Melo,J.R.; Brasileiro-Filho,G.; Pena,S.D.J.. Two different pathogenetic mechanisms are proposed for colorectal cancers. One, the so-called "classic pathway", is the most common and depends on multiple additive mutational events (germline and/or somatic) in tumor suppressor genes and oncogenes, frequently involving chromosomal deletions in key genomic regions. Methodologically this pathway is recognizable by the phenomenon of loss of heterozygosity. On the other hand, the "mutator pathway" depends on early mutational loss of the mismatch repair system (germline and/or somatic) leading to accelerated accumulation of gene mutations in critical target genes and progression to malignancy. Methodologically this second pathway is recognizable by the phenomenon of microsatellite instability. The distinction... Tipo: Info:eu-repo/semantics/article Palavras-chave: Polymerase chain reaction; Colorectal carcinoma; Microsatellite; P53; DCC; Microsatellite instability. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800001 p.F508del in a heterogeneous cystic fibrosis population from Minas Gerais, Brazil BJMBR Vidigal,P.V.T.; Reis,F.J.C.; Boson,W.L.M.; De Marco,L.A.; Brasileiro-Filho,G.. Cystic fibrosis (CF) is the most common autosomal recessive disease of the Caucasian population. Among the various CF mutations, p.F508del is the most frequent, accounting for two-thirds of the global CF chromosomes, although showing great variability among populations. We have studied 115 unrelated CF patients from a mixed population of Minas Gerais (Brazil). To evaluate part of the DNA sequence of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, blood DNA was obtained and PCR was performed using two pairs of primers that anneal to exons 10 and 24 of the CFTR gene. The PCR product was then submitted to automatic sequencing using the ABI PRISM 310 Genetic Analyzer. The p.F508del mutation was found in 50 (21.7%) of 230 unrelated CF... Tipo: Info:eu-repo/semantics/other Palavras-chave: Cystic fibrosis; P.F508del; Cystic fibrosis transmembrane conductance regulator. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800001 Morphological changes of the jejunal mucosa in protracted diarrhea and their correlation with disease duration, weight loss and serum albumin levels BJMBR Péret-Filho,L.A.; Brasileiro-Filho,G.; Penna,F.J.. The pathogenesis of protracted diarrhea is multifactorial. In developing countries, intestinal infectious processes seem to play an important role in triggering the syndrome. Thirty-four children aged 1 to 14 months, mean 6.5 months, with protracted diarrhea were studied clinically and in terms of small intestinal mucosal morphology. Mild, moderate or severe hypotrophy of the jejunal mucosa was detected in 82% of cases, and mucosal atrophy was observed in 12%. The intensity of the morphological changes of the jejunal mucosa correlated negatively with serum albumin levels. No correlation was detected between mucosal grading and duration of diarrhea or between mucosal grading and weight reported as percentile. After nutritional support was instituted, serial... Tipo: Info:eu-repo/semantics/article Palavras-chave: Protracted diarrhea; Biopsy; Jejunal mucosa; Serum albumin. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000900004 Monitoring human cytomegalovirus viral load in peripheral blood leukocytes of renal transplant recipients by a simple limiting dilution-PCR assay BJMBR Caballero,O.L.; Costa,M.C.S.L.; Trevisan,A.; Oliveira,R.M.; Viotti,E.A.; Távora,E.R.F.; Vilaça,S.S.; Sabagga,E.; de-Paula,F.J.; Távora,P.F.; Brasileiro-Filho,G.; Villa,L.L.; Simpson,A.J.G.. To assess the clinical relevance of a semi-quantitative measurement of human cytomegalovirus (HCMV) DNA in renal transplant recipients within the typical clinical context of a developing country where virtually 100% of both receptors and donors are seropositive for this virus, we have undertaken HCMV DNA quantification using a simple, semi-quantitative, limiting dilution polymerase chain reaction (PCR). We evaluated this assay prospectively in 52 renal transplant patients from whom a total of 495 serial blood samples were collected. The samples scored HCMV positive by qualitative PCR had the levels of HCMV DNA determined by end-point dilution-PCR. All patients were HCMV DNA positive during the monitoring period and a diagnosis of symptomatic infection was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Polymerase chain reaction; Human cytomegalovirus; Renal transplant; Diagnosis; Viral load. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200010 Registros recuperados: 4 Primeira ... 1 ... Última

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