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Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives Anais da ABC (AABC)
GOMES,ANA T.P.C.; NEVES,MARIA G.P.M.S.; CAVALEIRO,JOSÉ A.S..
ABSTRACT This review has two parts. The first one gives an approach to interdisciplinary studies against cancer carried out by many scientists using porphyrin-type substrates as photosensitizers in PDT. Intensive studies were performed for almost six decades. The successes really started in 1993 with the first formulation patented under the trade name Photofrin, which was immediately approved in several countries to treat certain types of cancer. Photofrin is still used although certain negative features soon became well known. That has motivated the search for better new photosensitizers. Several ones were developed, evaluated and a few of them had clinical approval. This group includes porphyrin derivatives and pro-drugs (aminolevulinic acid and its...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; Photodynamic Therapy; Porphyrins; Chlorins; Related macrocycles.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000300993
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Chemistry and Health: Past, Present and Future Anais da ABC (AABC)
CAVALEIRO,JOSÉ A.S..
Tipo: Info:eu-repo/semantics/other
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000300991
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Evaluation of meso-substituted cationic corroles as potential antibacterial agents Anais da ABC (AABC)
CARDOTE,TERESA A.F.; BARATA,JOANA F.B.; AMADOR,CAROLINA; ALVES,ELIANA; NEVES,MARIA GRAÇA P.M.S.; CAVALEIRO,JOSÉ A.S.; CUNHA,ÂNGELA; ALMEIDA,ADELAIDE; FAUSTINO,MARIA AMPARO F..
ABSTRACT Cationic derivatives of 5,10,15-tris[4-(pyridin-4-ylsulphanyl)-2,3,5,6-tetrafluorophenyl]-corrolategallium(III)pyridine and 5,10,15-tris[4-(pyridin-2-ylsulfanyl)-2,3,5,6-tetrafluorophenyl]-correlategallium(III)pyridine were synthesized and their photosensitizing properties against the naturally bioluminescent Gram-negative bacterium Allivibrio fischeri were evaluated. The cationic corrole derivatives exhibited antibacterial activity at micromolar concentrations against this Gram-negative bacterium strain.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Allivibrio fischeri; Corroles; Photosensitizer; PDI; Bioluminescence.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301175
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