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| CUENCA,JIMENA; PÉREZ,CLAUDIO A.; AGUIRRE,ADAM J.; SCHIATTINO,IRENE; AGUILLÓN,J. CARLOS. |
| Several single-nucleotide polymorphisms have been identified in the human TNF gene promoter. The polymorphism at position _308 (TNF-308), which involves substituting G for A and designing the TNF2 allele, leads to a higher rate of TNF gene transcription than the wild-type TNF1 allele in in vitro expression studies. It has also been linked to increased susceptibility to a variety of illnesses. Using PCR-RFLP analysis we detected significant differences in the TNF-308 genotypes of Chilean and other populations. We conclude that there is a gradient in the distribution of the TNF2 allele according to ethnicity; we have also hypothesized that populations bearing a higher proportion of the TNF2 allele may have an increased predisposition toward or incidence of... |
| Tipo: Journal article |
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| Ano: 2001 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000300011 |
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| SCHIATTINO,IRENE; VILLEGAS,RODRIGO; CRUZAT,ANDREA; CUENCA,JIMENA; SALAZAR,LORENA; ARAVENA,OCTAVIO; PESCE,BÁRBARA; CATALÁN,DIEGO; LLANOS,CAROLINA; CUCHACOVICH,MIGUEL; AGUILLÓN,JUAN C. |
| Longitudinal studies aimed at evaluating patients clinical response to specific therapeutic treatments are frequently summarized in incomplete datasets due to missing data. Multivariate statistical procedures use only complete cases, deleting any case with missing data. MI and MIANALYZE procedures of the SAS software perform multiple imputations based on the Markov Chain Monte Carlo method to replace each missing value with a plausible value and to evaluate the efficiency of such missing data treatment. The objective of this work was to compare the evaluation of differences in the increase of serum TNF concentrations depending on the 308 TNF promoter genotype of rheumatoid arthritis (RA) patients receiving anti-TNF therapy with and without multiple... |
| Tipo: Journal article |
Palavras-chave: Multiple imputation; Mixed model; TNF polymorphism. |
| Ano: 2005 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000100002 |
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