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| Cavalcanti,Isabella Macário Ferro; Menezes,Talita Gomes Calaça; Campos,Luís André de Almeida; Ferraz,Milena Sales; Maciel,Maria Amélia Vieira; Caetano,Maria Nelly Psiotano; Santos-Magalhães,Nereide Stela. |
| ABSTRACT The treatment of infections caused by resistant microorganisms is limited, and vancomycin (VAN) treatment failures for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia are not uncommon, even when MRSA clinical isolates are susceptible to VAN. Thus, this study proposed the association of VAN with usnic acid and β-lapachone encapsulated into liposomes as a novel therapeutic option for infections caused by MRSA. Liposomes containing β-lap (β-lap-lipo) or usnic acid (UA-lipo) were prepared by the thin lipid film hydration method followed by sonication. Antimicrobial activity against MRSA clinical isolates was investigated by the microdilution method according to the Clinical and Laboratory Standards Institute (CLSI). The interaction... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Β-lapachone; Usnic acid; Liposomes; Methicillin-resistant Staphylococcus aureus (MRSA); Synergism.. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200627 |
