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| Lima,Francisca Lúcia de; Farias,Flávio Furtado de; Campos,Patrícia Cota; Totola,Antônio Helvécio; Tavares,Carlos Alberto Pereira; Costa,José Eustáquio da; Farias,Luiz de Mácêdo; Carvalho,Maria Auxiliadora Roque de. |
| Actinobacillus actinomycetemcomitans is a clinically relevant periodontopathogenic Gram-negative coccobacillus that produces a leukotoxin of the RTX cytolysin family. In this study, we evaluated the leukotoxic activity of A. actinomycetemcomitans strains isolated from human and marmosets by Trypan blue exclusion and by the chemiluminescence assays. Among eight A. actinomycetemcomitans human strains studied, two (P2.17 and P8.12) were classified as high leukotoxin producers and among eight marmoset strains, one (M22.11) showed high leukotoxin production, as determined by Trypan blue exclusion assay. The reference strains ATCC 29523 and FDC Y4 respectively behaved like moderate and low producers. The chemiluminescence assay was used to evaluate the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Actinobacillus actinomycetemcomitans; Periodontopathogen; Leukotoxic activity; Chemiluminescence assay. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822001000300018 |
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| Campos,Patrícia Cota; Melo,Lutiana Amaral de; Dias,Gabriel Latorre Fortes; Fortes-Dias,Consuelo Latorre. |
| Abstract The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs). Most, if not all sbPLIs are oligomeric glycosylated proteins, although the carbohydrate moiety may not be essential for PLA2 inhibition in every case. The presently known sbPLIs belong to one of three structural classes – namely sbαPLI, sbβPLI or sbγPLI – depending on the presence of characteristic C-type lectin-like domains, leucine-rich repeats or three-finger motifs, respectively. Currently, the most numerous inhibitors described in the literature are sbαPLIs... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: PLA2 inhibitor; Phospholipase A2; Snake blood; Natural resistance; Snakes. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100204 |
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