|
|
|
|
|
| Carneiro-Júnior,M.A.; Quintão-Júnior,J.F.; Drummond,L.R.; Lavorato,V.N.; Drummond,F.R.; Amadeu,M.A.; Oliveira,E.M.; Felix,L.B.; Cruz,J.S.; Mill,J.G.; Natali,A.J.; Prímola-Gomes,T.N.. |
| In cardiomyocytes, calcium (Ca2+) release units comprise clusters of intracellular Ca2+ release channels located on the sarcoplasmic reticulum, and hypertension is well established as a cause of defects in calcium release unit function. Our objective was to determine whether endurance exercise training could attenuate the deleterious effects of hypertension on calcium release unit components and Ca2+ sparks in left ventricular myocytes of spontaneously hypertensive rats. Male Wistar and spontaneously hypertensive rats (4 months of age) were divided into 4 groups: normotensive (NC) and hypertensive control (HC), and normotensive (NT) and hypertensive trained (HT) animals (7 rats per group). NC and HC rats were submitted to a low-intensity treadmill running... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Physical activity; Hypertension; Cardiomyocyte; Calcium handling; Sarcoplasmic reticulum. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100960 |
| |
|
|
| Carneiro-Júnior,M.A.; Pelúzio,M.C.G.; Silva,C.H.O.; Amorim,P.R.S.; Silva,K.A.; Souza,M.O.; Castro,C.A.; Roman-Campos,D.; Prímola-Gomes,T.N.; Natali,A.J.. |
| We determined the effects of exercise training and detraining on the morphological and mechanical properties of left ventricular myocytes in 4-month-old spontaneously hypertensive rats (SHR) randomly divided into the following groups: sedentary for 8 weeks (SED-8), sedentary for 12 weeks (SED-12), treadmill-running trained for 8 weeks (TRA, 16 m/min, 60 min/day, 5 days/week), and treadmill-running trained for 8 weeks followed by 4 weeks of detraining (DET). At sacrifice, left ventricular myocytes were isolated enzymatically, and resting cell length, width, and cell shortening after stimulation at a frequency of 1 Hz (~25°C) were measured. Cell length was greater in TRA than in SED-8 (161.30 ± 1.01 vs 156.10 ± 1.02 μm, P < 0.05, 667 vs 618 cells,... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Physical activity; Inactivity; Hypertension; Cardiomyocytes. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100005 |
| |
|
|
|
