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	Provedor de dados Biol. Res. (1) Autor Carreño,Leandro J (1) Kalergis,Alexis M (1) Llanos,Carolina (1) Palavra-chave Autoimmunity (1) Dendritic cells (1) Immunological synapse (1) T cells (1) Tolerance (1) Tipo do documento Journal article (1) Ano 2011 (1) País Chile (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity Biol. Res. Llanos,Carolina; Carreño,Leandro J; Kalergis,Alexis M. Under healthy conditions, there is a balance between tolerance to self-tissue constituents and immunity against foreign antigens. Autoimmunity diseases (AD) take place when that equilibrium is disrupted and the immune response is directed to self-antigens, leading to injury or destruction of host tissues. The mechanisms conducing to the loss of immune tolerance remain largely unknown. The recent appearance of biological therapies has contributed to significant reduction in morbidity. However, currently available therapies are associated with important side effects and work only as palliative treatments. Dendritic cells (DCs) have emerged as key players in developing and maintaining adaptive immunity due to their capacity to prime and modulate T cell... Tipo: Journal article Palavras-chave: Dendritic cells; T cells; Immunological synapse; Autoimmunity; Tolerance. Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100007 Registros recuperados: 1 Primeira ... 1 ... Última

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