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Protein microarray for complex apoptosis monitoring of dysplastic oral keratinocytes in experimental photodynamic therapy Biol. Res.
Matei,Clara; Tampa,Mircea; Caruntu,Constantin; Ion,Rodica-Mariana; Georgescu,Simona-Roxana; Dumitrascu,Georgiana Roxana; Constantin,Carolina; Neagu,Monica.
BACKGROUND: Photodynamic therapy is an alternative treatment of muco-cutaneous tumors that uses a light source able to photoactivate a chemical compound that acts as a photosensitizer. The phthalocyanines append to a wide chemical class that encompasses a large range of compounds; out of them aluminium-substituted disulphonated phthalocyanine possesses a good photosensitizing potential. RESULTS: The destructive effects of PDT with aluminium-substituted disulphonated phthalocyanine are achieved by induction of apoptosis in tumoral cells as assessed by flow cytometry analysis. Using protein microarray we evaluate the possible molecular pathways by which photodynamic therapy activates apoptosis in dysplastic oral keratinocytes cells, leading to the tumoral...
Tipo: Journal article Palavras-chave: Aluminum di-sulphonated phthalocyanine; DOK cells; Photodynamic therapy; Protein microarray.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100033
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