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| Pinheiro,D.F.; Pacheco,P.D.G.; Alvarenga,P.V.; Buratini Jr,J.; Castilho,A.C.S.; Lima,P.F.; Sartori,D.R.S.; Vicentini-Paulino,M.L.M.. |
| This study investigated the consequences of intrauterine protein restriction on the gastrointestinal tract and particularly on the gene expression and activity of intestinal disaccharidases in the adult offspring. Wistar rat dams were fed isocaloric diets containing 6% protein (restricted, n = 8) or 17% protein (control, n = 8) throughout gestation. Male offspring (n = 5-8 in each group) were evaluated at 3 or 16 weeks of age. Maternal protein restriction during pregnancy produced offspring with growth restriction from birth (5.7 ± 0.1 vs 6.3 ± 0.1 g; mean ± SE) to weaning (42.4 ± 1.3 vs 49.1 ± 1.6 g), although at 16 weeks of age their body weight was similar to control (421.7 ± 8.9 and 428.5 ± 8.5 g). Maternal protein restriction also increased lactase... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MRNA enzyme abundance; Maternal protein restriction; Disaccharidase activity; Fetal programming. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300287 |
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