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Mutation rate of 7 X-STRs of common use in population genetics JBAG
Glesmann,Laura A.; Martina,Pablo F.; Vidal Rioja,Lidia; Catanesi,Cecilia I..
Microsatellite loci analysis is a relevant tool in population genetic studies and also in paternity testing. In this field the X-chromosome STR loci are widely used for female offspring testing but their mutation rates are scarcely known. In this work we performed a mutation rate analysis of seven STR markers located in the X- chromosome specific region, in mother-son pairs and father-mother-daughter trios. Among 1015 allele transfers, we found only one change for a mother-daughter transmission in the DXS9898 locus, consisting of a loss of one single repeat. This finding allowed us to estimate a general mutation rate of μ=9.85 x 10-4 (2.49 x 10-4 - 5.49 x 10-2) which can be applied to population studies. This value is consistent with other reports...
Tipo: Info:eu-repo/semantics/article Palavras-chave: X chromosome; STR; Mutation rate; Population genetics.
Ano: 2009 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332009000200002
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Molecular and phylogenetic analysis of mitochondrial control region in Robertsonian karyomorphs of Graomys griseoflavus (Rodentia, Sigmodontinae) Mastozool. neotrop.
Catanesi,Cecilia I.; Vidal-Rioja,Lidia; Zambelli,Andrés.
The South American rodent Graomys griseoflavus is a species with a Robertsonian (Rb) autosomal polymorphism. A marked genetic differentiation between 2n=42-41 and 2n=38-34 karyomorphic groups was evidenced by cytogenetic and molecular analysis. The mitochondrial control region was sequenced in all Graomys karyomorphs for its characterization and used to trace more accurate phylogenetic relationships. The molecular organization showed to be coincident with the consensus molecular structure described for other rodent taxa, exhibiting the conserved domains ETAS (extended termination-associated sequences), CD (central domain) and CSB (conserved sequence block) 1, 2 and 3. Phylogenetic trees showed that 2n=42-41 and 2n=38-34 karyomorphic groups form separate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rodentia; Graomys; Robertsonian polymorphism; MtDNA; Phylogeny.
Ano: 2006 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-93832006000100003
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