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Pullulan as a stabilizer agent of polymeric nanocapsules for drug delivery BJPS
Chassot,Janaíne Micheli; Ferreira,Luana Mota; Gomes,Felipe Pereira; Silva,Cristiane de Bona da; Tasso,Leandro; Cruz,Letícia.
ABSTRACT Polymeric stabilizers have received attention in the preparation of nanostructured systems due to their ability to enhance formulation stability. Considering this, the objective of this work was to prepare poly(ε-caprolactone) nanocapsules using the pullulan as a polymeric stabilizer. The nanocapsules were prepared using the interfacial deposition method of preformed polymers and they were characterized in terms of pH, average diameter, polydispersity index, zeta potential, beclomethasone dipropionate content, encapsulation efficiency, photostability and drug release profiles. The formulations showed physicochemical characteristics consistent with nanocarriers for drug delivery such as: average diameter lower than 270 nm, polydispersity indexes...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pullulan; Nanocapsules/diffusion technique; Pullulan/polymeric stabilizer; Biocompatible polymers; Beclomethasone dipropionate/nanocapsules..
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400735
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Stability-indicating RP-HPLC method for determination of beclomethasone dipropionate in nanocapsule suspensions BJPS
Chassot,Janaíne Micheli; Ferreira,Luana Mota; Gomes,Felipe Pereira; Cruz,Letícia; Tasso,Leandro.
abstract A simple stability-indicating RP-HPLC/UV method was validated for determination of beclomethasone dipropionate (BD) in nanocapsule suspensions. Chromatographic conditions consisted of a RP C18column (250 mm x 4.60 mm, 5 µm, 110 Å), using methanol and water (85:15 v/v) as mobile phase at 1.0 mL/min with UV detection at 254 nm. The calibration curve was found to be linear in the concentration range of 5.0-25.0 µg/mL with a correlation coefficient > 0.999. Precision was demonstrated by a relative standard deviation lower than 2.0%. Accuracy was assessed by the recovery test of BD from nanocapsules (98.03% to 100.35%). Specificity showed no interference from the components of nanocapsules or from the degradation products derived from acid, basic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: High performance liquid chromatography/reverse phase/quantitative analysis; Beclomethasone dipropionate/determination; Nanocapsule/suspensions; Nanoparticles..
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400803
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