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| Yan,Jingyi; Chen,Didi; Chen,Xiaolei; Sun,Xuecheng; Dong,Qiantong; Hu,Changyuan; Zhou,Feng; Chen,Wei. |
| Imatinib is the first line of therapy for patients with metastatic or gastrointestinal stromal tumors (GIST). However, drug resistance limits the long-term effect of imatinib. Long non-coding RNAs (lncRNAs) are emerging as key players in regulating drug resistance in cancer. In this study, we investigated the association between lncRNA CCDC26 and IGF-1R in GIST and their involvement in drug resistance. Considering the key role of lncRNAs in drug resistance in cancer, we hypothesized that IGF-1R is regulated by lncRNAs. The expression of a series of reported drug resistance-related lncRNAs, including CCDC26, ARF, H19, NBR2, NEAT1, and HOTAIR, in GIST cells treated with imatinib H19 was examined at various time-points by qRT-PCR. Based on our results and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Long non-coding RNA CCDC26; Gastrointestinal stromal tumors; GIST; IGF-1R; Imatinib resistance. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000600610 |
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