|
|
|
|
|
Chen,Jun; Chen,Zhifei; Li,Yuanyuan; Xia,Wei; Chen,Xi; Chen,Tian; Zhou,Liping; Xu,Bin; Xu,Shunqing. |
OBJECTIVE: The study aimed to investigate gyrA and gyrB mutations in Mycobacterium tuberculosis (MTB) clinical strains from 93 patients with pulmonary tuberculosis in Hubei Province, China, and analyze the association between mutation patterns of the genes and ofloxacin resistance level. RESULTS: Among 93 MTB clinical isolates, 61 were ofloxacin-resistant by the proportion method, and 32 were ofloxacin-susceptible MDR-TB. No mutation in the gyrB gene was found in any MTB strains. In the 61 ofloxacin-resistant isolates, 54 mutations were observed in the gyrA gene. Only one mutation in the gyrA gene was found in ofloxacin-susceptible MDR-TB isolates. In this study, the mutation patterns of gyrA involved seven patterns of single codon mutation (A90V, S91P,... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mycobacterium tuberculosis; Fluoroquinolones; DNA mutational analysis. |
Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200005 |
| |
|
|
Geng,Tianxiang; Sun,Shouxuan; Yu,Haochen; Guo,Haohui; Zheng,Mengxue; Zhang,Shuai; Chen,Xi; Jin,Qunhua. |
The imbalance between bone formation and osteolysis plays a key role in the pathogenesis of aseptic loosening. Strontium ranelate (SR) can promote bone formation and inhibit osteolysis. The aim of this study was to explore the role and mechanism of SR in aseptic loosening induced by wear particles. Twenty wild-type (WT) female C57BL/6j mice and 20 sclerostin-/- female C57BL/6j mice were used in this study. Mice were randomly divided into four groups: WT control group, WT SR group, knockout (KO) control group, and KO SR group. We found that SR enhanced the secretion of osteocalcin (0.72±0.007 in WT control group, 0.98±0.010 in WT SR group, P=0.000), Runx2 (0.34±0.005 in WT control group, 0.47±0.010 in WT SR group, P=0.000), β-catenin (1.04±0.05 in WT... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Strontium ranelate; Aseptic loosening; Sclerostin; Bone remodeling; Canonical Wnt pathway. |
Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000900605 |
| |
|
|
|