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The radiation protection role of heparin-SOD conjugate in irradiated mice BJPS
Zhong,Chuanqing; Huang,Xiaojing; Zhang,Shu; Cheng,Yanna; Cao,Guangxiang; Wang,Fengshan.
ABSTRACT Heparin-SOD conjugate (Hep-SOD) was prepared by modifying Cu,Zn-SOD with heparin. An acute radiation-induced mouse injury model was constructed to study the radiation protection effects of Hep-SOD conjugate. Fifty-six mice were randomly divided into seven groups: (I) normal control group; (II) irradiated control group; (III) positive control group (amifostine group, 300 mg/kg); (IV) SOD group (35000 U/kg); (V) high dosage of Hep-SOD group (70000 U/kg); (VI) medium dosage of Hep-SOD group (35000 U/kg); (VII) low dosage of Hep-SOD group (17500 U/kg). Drugs were intraperitoneally injected into each mouse 1 h before radiation except for the normal control group. All the irradiated groups were irradiated with 6 Gy. Organ indices, haematopoietic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Heparin-superoxide dismutase conjugate; Radiation-induced damage; Oxidative stress injury.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400611
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