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Genetic variation in body weight gain and composition in the intercross of Large (LG/J) and Small (SM/J) inbred strains of mice Genet. Mol. Biol.
Kramer,Melissa G.; Vaughn,Ty T.; Pletscher,L. Susan; King-Ellison,Kelly; Adams,Emily; Erikson,Christopher; Cheverud,James M..
Strain intercross experiments provide a powerful means for mapping genes affecting complex quantitative traits. We report on the genetic variability of the intercross of the Large (LG/J) and Small (SM/J) inbred mouse strains as a guide to gene mapping studies. Ten SM/J males were crossed to 10 LG/J females, after which animals were randomly mated to produce F1, F2, and F3 intercross generations. The 1632 F3 animals from 200 full-sib families were used to estimate heritabilities and genetic correlations of the traits measured. A subset of families was cross-fostered at birth to allow measurement of the importance of post-natal maternal effects. Data was collected on weekly body weight from one to 10 weeks and on organ weights, body weight, reproductive fat...
Tipo: Info:eu-repo/semantics/article
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000200007
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Research Article Comparing covariance matrices: random skewers method compared to the common principal components model Genet. Mol. Biol.
Cheverud,James M.; Marroig,Gabriel.
Comparisons of covariance patterns are becoming more common as interest in the evolution of relationships between traits and in the evolutionary phenotypic diversification of clades have grown. We present parallel analyses of covariance matrix similarity for cranial traits in 14 New World Monkey genera using the Random Skewers (RS), T-statistics, and Common Principal Components (CPC) approaches. We find that the CPC approach is very powerful in that with adequate sample sizes, it can be used to detect significant differences in matrix structure, even between matrices that are virtually identical in their evolutionary properties, as indicated by the RS results. We suggest that in many instances the assumption that population covariance matrices are...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Covariance matrix; Common principal components; Random skewers; New World monkeys; Quantitative genetics.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000300027
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