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	Provedor de dados BJPS (1) Autor Chickpetty,Sidramappa Mallikarjun (1) Raga,Baswaraj Veerappa (1) Palavra-chave 5-fluorouracil (1) Colon cancer and X-ray (1) Colon targeting (1) Compression coated tablet (1) Locust bean gum (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Formulation, in vitro drug release and in vivo human X-ray investigation of polysaccharide based drug delivery systems for targeting 5-fluorouracil to the colon BJPS Chickpetty,Sidramappa Mallikarjun; Raga,Baswaraj Veerappa. The purpose of this research study was to develop 5-fluorouracil compression coated tablets by using biodegradable polysaccharide polymer locust bean gum (LBG) and hydroxyl propyl methyl cellulose (HPMC) as coating materials. The fast disintegrating core tablets containing 50 mg of 5-fluorouracil were compression coated with LBG and HPMC in different ratios (8:1, 7:2 and 6:3) with a coat weight of 300, 400 and 500 mg. In vitro dissolution data indicated that the formulation (CLH63) with a coat weight of 500 mg containing LBG and HPMC in the ratio 6:3 gave the best release profile (0% in first 5 hour and 96.18% in 24 hours). DSC and FTIR results indicated no possibility of interaction between drug and polymers or other excipients. In vivo human X-ray... Tipo: Info:eu-repo/semantics/article Palavras-chave: Compression coated tablet; Locust bean gum; Colon targeting; 5-fluorouracil; Colon cancer and X-ray. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200008 Registros recuperados: 1 Primeira ... 1 ... Última

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