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PROGRESSIVE EFFECTS OF DIABETES MELLITUS ON THE SKIN EPITHELIUM OF THE RA International Journal of Morphology
Benetti Tanga,Marcelo; Buttros,Kemli Raquel; Nakao,Cristiano; Chinali Komesu,Marilena.
Skin serves as interface between inner aand outer environment, and acts a a mechanical barrier. Changes in its characteristics may lead to a higher pathogenicity, less defense capacity, or both. Diabetes mellitus is a heterogeneous group of chronic hyperglycemic disorders, considered a syndrome rather than a simple disease. Complications by diabetes are mostly associated with the chronicity of the disease and very little information exists about its early pathological processes. Animal models are considered very useful for the study of early diabetes. Wistar rats with lloxan induccced diabetes were used in a way to study the progresive effects of diabetes mellitus on the skin epithelium. Five animals were sacrificed at 7 days (Phase I) and five others at...
Tipo: Journal article Palavras-chave: Diabetes mellitus; Hyperglycemia; Skin; Rat.
Ano: 2003 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000200008
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Immune Cells Depletion During Wound Healing as a Long-Term Effect of Undernutrition International Journal of Morphology
Zuanassi Macari,Marcelo; Misael Cavenaghi,Fabiano; Chinali Komesu,Marilena; Orive Lunardi,Laurelúcia; Sala,Miguel Angel; Novaes Júnior,Arthur Belém; Grisi,Márcio Fernando de Moraes; Taba Júnior,Mário; Scombatti de Souza,Sérgio Luiz.
Undernutrition in early life is associated with a number of acute and chronic sequelae, and recovering is a controversial issue. Even if undernutrition in Brazil is declining, studies have shown that about 31% of brazilian children still present severe or moderate malnutrition. The present study goal was to induce early malnutrition in rats and observe short- (undernourished) and long-term (after recovered) effects on defense cells involved in wound healing. Undernutrition was produced by separating the pups from the mother for 10 hours/day during the suckling period (21 days after birth). As controls were used rats at same age not submitted to suckling restriction. Undernutrition and recovering states were assessed by body weight. Skin wounds were made on...
Tipo: Journal article Palavras-chave: Undernourishment; Wound healing; Defense cells.
Ano: 2005 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000100005
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