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Differential effects of isoproterenol on the activity of angiotensin-converting enzyme in the rat heart and aorta BJMBR
Busatto,V.C.W.; Cunha,V.; Cicilini,M.A.; Mill,J.G..
The excessive stimulation of beta-adrenergic receptors in the heart induces myocardial hypertrophy. There are several experimental data suggesting that this hypertrophy may also depend, at least partially, on the increase of local production of angiotensin II secondary to the activation of the cardiac renin-angiotensin system. In this study we investigated the effects of isoproterenol on the activity of angiotensin-converting enzyme (ACE) in the heart and also in the aorta and plasma. Male Wistar rats weighing 250 to 305 g were treated with a dose of (±)-isoproterenol (0.3 mg kg-1 day-1, N = 8) sufficient to produce cardiac hypertrophy without deleterious effects on the pumping capacity of the heart. Control rats (N = 7) were treated with vehicle (corn...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Angiotensin-converting enzyme; Isoproterenol; Cardiac hypertrophy; Myocardial infarction; Heart failure.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000300017
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Roles of estrogen and progesterone in modulating renal nerve function in the rat kidney BJMBR
Graceli,J.B.; Cicilini,M.A.; Bissoli,N.S.; Abreu,G.R.; Moysés,M.R..
The maintenance of extracellular Na+ and Cl- concentrations in mammals depends, at least in part, on renal function. It has been shown that neural and endocrine mechanisms regulate extracellular fluid volume and transport of electrolytes along nephrons. Studies of sex hormones and renal nerves suggested that sex hormones modulate renal function, although this relationship is not well understood in the kidney. To better understand the role of these hormones on the effects that renal nerves have on Na+ and Cl- reabsorption, we studied the effects of renal denervation and oophorectomy in female rats. Oophorectomized (OVX) rats received 17β-estradiol benzoate (OVE, 2.0 mg·kg-1·day-1, sc) and progesterone (OVP, 1.7 mg·kg-1·day-1,sc). We assessed Na+ and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Estrogen; Na+ and Cl- reabsorption; Progesterone; Renal nerve.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000600521
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