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| Fontoura,I. C.; Trombone,A.P.F.; Almeida,L. P.; Lorenzi,J. C. C.; Rossetti,R. A. M.; Malardo,T.; Padilha,E.; Schluchting,W.; Silva,R. L. L.; Gembre,A. F.; Fiuza,J. E. C.; Silva,C. L.; Panunto-Castelo,A.; Coelho-Castelo,A. A. M.. |
| In DNA vaccines, the gene of interest is cloned into a bacterial plasmid that is engineered to induce protein production for long periods in eukaryotic cells. Previous research has shown that the intramuscular immunization of BALB/c mice with a naked plasmid DNA fragment encoding the Mycobacterium leprae 65-kDa heat-shock protein (pcDNA3-Hsp65) induces protection against M. tuberculosis challenge. A key stage in the protective immune response after immunization is the generation of memory T cells. Previously, we have shown that B cells capture plasmid DNA-Hsp65 and thereby modulate the formation of CD8+ memory T cells after M. tuberculosis challenge in mice. Therefore, clarifying how B cells act as part of the protective immune response after DNA... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: DNA-Hsp65 vaccine; Memory T cells; B cells. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001201095 |
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