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	Provedor de dados BJMBR (4) Autor Coimbra,C.G. (4) Junqueira,V.B.C. (2) Borges,A.A. (1) Favero-Filho,L.A. (1) Grassl,C. (1) Lopes,A.C. (1) Sinigaglia-Coimbra,R. (1) Mais... Palavra-chave Ischemic penumbra (2) Apnea test (1) Brain death (1) Cerebral ischemia (1) Flavin-adenine dinucleotide (1) Glutathione (1) Hemin (1) Hyperthermia (1) Hypothermia (1) Intracranial pressure (1) Iron (1) Neurodegeneration (1) Parkinson's disease (1) Rat focal ischemia (1) Riboflavin (1) Thrombolysis (1) Traumatic brain injury (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Info:eu-repo/semantics/other (1) Ano 2008 (1) 2004 (1) 2003 (1) 1999 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients BJMBR Coimbra,C.G.; Junqueira,V.B.C.. Abnormal riboflavin status in the absence of a dietary deficiency was detected in 31 consecutive outpatients with Parkinson's disease (PD), while the classical determinants of homocysteine levels (B6, folic acid, and B12) were usually within normal limits. In contrast, only 3 of 10 consecutive outpatients with dementia without previous stroke had abnormal riboflavin status. The data for 12 patients who did not complete 6 months of therapy or did not comply with the proposed treatment paradigm were excluded from analysis. Nineteen PD patients (8 males and 11 females, mean age ± SD = 66.2 ± 8.6 years; 3, 3, 2, 5, and 6 patients in Hoehn and Yahr stages I to V) received riboflavin orally (30 mg every 8 h) plus their usual symptomatic medications and all red... Tipo: Info:eu-repo/semantics/article Palavras-chave: Parkinson's disease; Riboflavin; Flavin-adenine dinucleotide; Glutathione; Iron; Hemin. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000019 Implications of ischemic penumbra for the diagnosis of brain death BJMBR Coimbra,C.G.. The data reviewed here suggest the possibility that a global reduction of blood supply to the whole brain or solely to the infratentorial structures down to the range of ischemic penumbra for several hours or a few days may lead to misdiagnosis of irreversible brain or brain stem damage in a subset of deeply comatose patients with cephalic areflexia. The following proposals are advanced: 1) the lack of any set of clinically detectable brain functions does not provide a safe diagnosis of brain or brain stem death; 2) apnea testing may induce irreversible brain damage and should be abandoned; 3) moderate hypothermia, antipyresis, prevention of arterial hypotension, and occasionally intra-arterial thrombolysis may contribute to good recovery of a possibly... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ischemic penumbra; Cerebral ischemia; Intracranial pressure; Traumatic brain injury; Brain death; Hypothermia; Thrombolysis; Apnea test. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200005 Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain BJMBR Favero-Filho,L.A.; Borges,A.A.; Grassl,C.; Lopes,A.C.; Sinigaglia-Coimbra,R.; Coimbra,C.G.. Chronic neurodegenerative processes have been identified in the rat forebrain after prolonged survival following hyperthermia (HT) initiated a few hours after transient global ischemia. Since transient global ischemia and ischemic penumbra share pathophysiological similarities, this study addressed the effects of HT induced after recirculation of focal brain ischemia on infarct size during long survival times. Adult male Wistar rats underwent intra-luminal occlusion of the left middle cerebral artery for 60 min followed by HT (39.0-39.5°C) or normothermia. Control procedures included none and sham surgery with and without HT, and middle cerebral artery occlusion alone. Part I: 6-h HT induced at recirculation. Part II: 2-h HT induced at 2-, 6-, or 24-h... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hyperthermia; Ischemic penumbra; Neurodegeneration; Rat focal ischemia. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001100014 Response to the Comments of H.B. Ferraz et al. about the paper "High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients. C.G. Coimbraand V.B.C. Junqueira. Brazilian Journal of Medical and Biological Research, 36: 1409-1417, 2003" BJMBR Coimbra,C.G.; Junqueira,V.B.C.. Tipo: Info:eu-repo/semantics/other Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000900003 Registros recuperados: 4 Primeira ... 1 ... Última

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