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| Comini-Frota,E.R.; Rodrigues,D.H.; Miranda,E.C.; Brum,D.G.; Kaimen-Maciel,D.R.; Donadi,E.A.; Teixeira,A.L.. |
| The objective of the present study was to determine if there is a relationship between serum levels of brain-derived neurotrophic factor (BDNF) and the number of T2/fluid-attenuated inversion recovery (T2/FLAIR) lesions in multiple sclerosis (MS). The use of magnetic resonance imaging (MRI) has revolutionized the study of MS. However, MRI has limitations and the use of other biomarkers such as BDNF may be useful for the clinical assessment and the study of the disease. Serum was obtained from 28 MS patients, 18-50 years old (median 38), 21 women, 0.5-10 years (median 5) of disease duration, EDSS 1-4 (median 1.5) and 28 healthy controls, 19-49 years old (median 33), 19 women. BDNF levels were measured by ELISA. T1, T2/FLAIR and gadolinium-enhanced lesions... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Multiple sclerosis; Biomarkers; Neurotrophins; BDNF; Neuroimaging. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100011 |
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