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Apoptosis as a prognostic marker in canine mammary tumors by TUNEL 62
Pereira,Kariny Sanches; Zuccari,Débora Aparecida Pires de Campos; Cury,Patrícia Maluf; Cordeiro,José Antônio.
Apoptosis plays an important role in oncogenesis determining tumor growth and aggressiveness. The aim of this study was to examine the relationship between apoptosis, diagnosis and prognosis in canine mammary tumors. Thirty bitches were submitted to tumor extirpation and a method of labeling apoptotic cells, that labels DNA fragments, by terminal deoxynucleotidyl-tranferase (TdT) mediated by 5' deoxy-uridine-triphosphate (dUTP) nick and labeling (TUNEL) was used. The apoptotic cells were counted in ten high power fields (10HPF). Statistical results showed that when there are more than 30 apoptotic cells/10HPF the prognosis is worse (p= 0,0005). Thus suggesting that apoptosis can be used as a prognostic marker in canine breast tumors.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Apoptosis; Prognosis; Breast cancer; Bitch.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95962003000500007
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Effects of caffeine on mitotic index in Drosophila prosaltans (Diptera) 54
Itoyama,Mary Massumi; Bicudo,Hermione Elly Melara de Campos; Cordeiro,José Antônio.
The effect of two concentrations of caffeine (1500 <FONT FACE="Symbol">m</FONT>g/ml and 2500 <FONT FACE="Symbol">m</FONT>g/ml) on mitotic indices of Drosophila prosaltans was analyzed in larval brain cells. Although the differences detected between treated and control cells were not significant, the percentages obtained suggest a possible effect of caffeine in slowing the process of cell division
Tipo: Info:eu-repo/semantics/other
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000400016
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