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| Cortez,Alane Pereira; Menezes,Elizabeth Gomes Paulino; Benfica,Polyana Lopes; Santos,Alexandre Pereira dos; Cleres,Larissa Moreira; Ribeiro,Higor de Oliveira; Lima,Eliana Martins; Kato,Massuo Jorge; Valadares,Marize Campos. |
| Abstract In this study, the potential antileukemic activity of grandisin, a lignan extracted from Piper solmsianum, was evaluated against the leukemic line K562. The cytotoxicity of grandisin (0.018 to 2.365 µM) was evaluated in K562 and normal peripheral blood lymphocytes by Trypan Blue Exclusion and MTT methods after 48h exposure to the drug. In both methods, cellular viability was concentration-dependent and the IC50 values were lower than 0.85µM. Analysis of K562 cells after treatment with grandisin showed that the cell cycle was arrested in the G1 phase with a 12.31% increase, while both S and G2 phases decreased. Morphological studies conducted after the exposure of K562 to grandisin revealed changes consistent with the apoptosis process, which was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Grandisin/antileukemic activities; Leukemic; K562; Apoptosis.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100610 |
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| Ávila,Renato Ivan de; Ferreira,Camila Carvalho; Alvarenga,Cátia Belo Mattos; Vieira,Marcelo de Sousa; Cortez,Alane Pereira; Batista,Aline Carvalho; Costa,Elson Alves; Valadares,Marize Campos. |
| This study evaluated the safety of Lafoensia pacari A. St.-Hil. (Lythraceae) stem bark hydroalcoholic extract (LPE) through acute and subchronic toxicological assessments in mice. In the acute toxicity evaluation, a single 2000 mg/kg oral dose of LPE was administered to mice and clinical observations were conducted for 14 days. For subchronic toxicity, LPE doses (6.25-1000 mg/kg) were administered orally for 28 days and biochemical, hematological, histopathological analyses and renal and liver expression of Ki-67 were carried out. The acute oral toxicity evaluation of LPE showed no toxicity in mice and it was was classified as category 5 (LD50>2000-5000 mg/kg). In a repeated dose 28-day toxicity study, LPE (100-1000 mg/kg) led to an increase in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mangava-brava; Lafoensia pacari/evaluation; Medicinal plant; Natural product. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100595 |
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