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Endothelial function and cardiovascular diseases in HIV infected patient BJID
Andrade,Ana Cristina O.; Cotter,Bruno R..
The HIV epidemic has dramatically changed the paradigm for the development of drug therapy in the last 15 years. The goal is now not only to provide an effective reduction of plasma viremia , but also to reconstitute the immune deficiency due to the progression of the disease. Significant problems with the metabolism of sugars and lipids lead to the appearance of well-documented disorders such as insulin resistance, abnormalities in lipid metabolism and lipodystrophy in those patients on prolonged therapy with antiretrovirals. The question of whether or not HAART-associated lipid disorders contribute to the premature development of coronary artery disease is of major importance for the HIV community. Endothelial injury is associated with disease-related...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Human immunodeficiency virus; Endothelial dysfunction; Endothelial adhesion molecules; Antiretroviral therapy; Cardiovascular risk factors; Atherosclerosis; Coronary heart disease.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200012
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