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	Provedor de dados ArchiMer (2) Autor Cresteil, Thierry (2) Debitus, Cecile (2) Bourguet-kondracki, Marie-lise (1) Copp, Brent R. (1) D'Auria, Maria Valeria (1) De Marino, Simona (1) Festa, Carmen (1) Kientz, Betty (1) Longeon, Arlette (1) Petek, Sylvain (1) Quevrain, Elodie (1) Roue, Melanie (1) Zampella, Angela (1) Mais... Palavra-chave Antioxidant (1) Bromoindoles (1) Cytotoxic (1) Hyrtios sp. (1) Indole derivatives (1) Marine cytotoxin (1) Marine sponge (1) PLA(2) inhibitor (1) Rhopaloeides odorabile (1) Swinholide J (1) Theonella swinhoei (1) Mais... Tipo do documento Text (2) Ano 2011 (2) País France (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp. ArchiMer Longeon, Arlette; Copp, Brent R.; Quevrain, Elodie; Roue, Melanie; Kientz, Betty; Cresteil, Thierry; Petek, Sylvain; Debitus, Cecile; Bourguet-kondracki, Marie-lise. Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A(2) (PLA(2)), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA2 inhibition (IC50 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29. Tipo: Text Palavras-chave: Indole derivatives; Bromoindoles; Marine sponge; Rhopaloeides odorabile; Hyrtios sp.; PLA(2) inhibitor; Antioxidant; Cytotoxic. Ano: 2011 URL: https://archimer.ifremer.fr/doc/00214/32485/30975.pdf Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei ArchiMer De Marino, Simona; Festa, Carmen; D'Auria, Maria Valeria; Cresteil, Thierry; Debitus, Cecile; Zampella, Angela. In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC(50) value of 6 nM. Tipo: Text Palavras-chave: Marine cytotoxin; Swinholide J; Theonella swinhoei. Ano: 2011 URL: https://archimer.ifremer.fr/doc/00214/32484/30974.pdf Registros recuperados: 2 Primeira ... 1 ... Última

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