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| Faleiro,Mariana Batista Rodrigues; Croce,Giuliana Brasil; Toledo,Denise Caroline; Rodrigues,Marcela Marcondes Pinto; Batista,Aline Carvalho; Damasceno,Adilson Donizeti; Brito,Luiz Augusto Batista; Amorim,Renée Laufer; Moura,Veridiana Maria Brianezi Dignani de. |
| In this study the expression of metalloproteinases 2 (MMP-2) and 9 (MMP-9) in canine normal prostates and with proliferative disorders was evaluated to verify the role of these enzymes in extracellular matrix remodeling (ECM) and in the tissue invasion process. A total of 355 prostatic samples were obtained, from which 36 (10.1%) were normal prostates, 46 (13.0%) with benign prostatic hyperplasia (BPH), 128 (36.1%) with proliferative inflammatory atrophy (PIA), 74 (20.8%) with prostatic intraepithelial neoplasia (PIN), and 71 (20.0%) with prostatic carcinoma (PC). Difference in cytoplasmic immunohistochemical staining of MMP-2 and MMP-9 between acinar epithelium and periacinar stroma was found regarding the different diagnosis. The correlation between... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Gelatinases; Benign prostatic hyperplasia; Proliferative inflammatory atrophy; Prostatic intraepithelial neoplasia; Prostatic carcinoma. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782013000600015 |
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