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| Pacheco,Alejandro; Daleprane,Julio B; Freitas,Vanessa S; Ferderbar,Simone; Hirabara,Sandro; Cuevas,Alejandro; Saavedra,Nicolás; Curi,Rui; Abdalla,Dulcineia S. P; Salazar,Luis A. |
| En el presente estudio se evaluó el efecto del propóleos sobre el metabolismo de la glucosa en ratones C57/BL-6 con diabetes mellitus tipo 2 inducida por dieta alta en grasa. Se midieron los cambios en las concentraciones séricas de lípidos, glucosa e insulina, y el efecto sobre la captación de 2-deoxi-[2,6-3H]-D-glucosa, síntesis de [14C]-glicógeno y descarboxilación de [U-14C]-D-glucosa inducida por insulina en músculo aislado. Los resultados muestran que en ratones diabéticos, el tratamiento con propóleos (150 mg/kg/día) reduce los niveles de insulina e índice HOMA (P<0.05). También disminuyó la obesidad abdominal de estos animales (P<0.05). Por otro lado, no modificó las concentraciones plasmáticas de glucosa, colesterol total y triglicéridos. Se... |
| Tipo: Journal article |
Palavras-chave: Propóleos; Ratones Diabéticos; Polifenoles; Glucosa. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300015 |
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| Márquez,José L; Hirabara,Sandro M; Fiamoncini,Jarlei; Hatanaka,Elaine; Alba-Loureiro,Tatiana C; Lima-Salgado,Thais M. de; Curi,Rui; Salazar,Luis A. |
| El Síndrome Metabólico corresponde a una serie de trastornos relacionados con obesidad e inactividad física. Poco se conoce respecto de la falta de ejercicio, en estadios tempranos del desarrollo, en la susceptibilidad a un fenotipo insulinoresistente inducido por una dieta alta en grasas. Akt juega un rol clave en la síntesis de proteínas y el transporte de glucosa en el músculo esquelético y ha mostrado ser regulada por la actividad muscular. El objetivo del presente estudio fue determinar el efecto de la inactividad física temprana sobre el crecimiento muscular y la susceptibilidad de adquirir un fenotipo diabético y evaluar su relación con la expresión de Akt. Cuarenta ratas Wistar fueron distribuidas en 2 grupos (Grupos Control, Std) y Restricción de... |
| Tipo: Journal article |
Palavras-chave: Akt; Inactividad física; Insulinoresistencia. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100043 |
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| Hernández,Alfonso; Curi,Rui; Salazar,Luis A. |
| Type 2 diabetes mellitus implies deregulation of multiple metabolic processes, being the maintenance of glycemia one of the most important. Many genes are involved in the deregulation of this particular process. Therefore, the aim of this study was to evaluate gene expression of genes related to type 2 diabetes mellitus, in the liver and pancreas of rats with hyperglycemia induced by high fat diet along with a low single dose of streptozotocin. Ahsg and Ppargc1a genes were studied in liver, whereas Kcnj11 and Slc2a2 genes were analyzed in pancreas. For this purpose, 210-240 g female rats were fed a high fat diet or a control diet for three weeks. At day 14, animals fed with high fat diet were injected with a single low dose of streptozotocin (35 mg/kg) and... |
| Tipo: Journal article |
Palavras-chave: Gene Expression; Hyperglycemia; Ppargcla. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200047 |
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| Silva,Gisleine Elisa Cavalcante da; Bazotte,Roberto Barbosa; Curi,Rui; Silva,Maria Angélica Rafaini Covas Pereira da. |
| The aim of this study was to investigate risk factors to coronary heart disease in two countryside villages in the State of Paraná, southern Brazil, typical in terms of the poverty and lack of access to public health care. All population was invited to participate in the study. The 462 volunteers (61.3% female, mean age = 42 years) showed high prevalence of hypercholesterolemia (7.0%), hypertriglyceridemia (19.0%), hyperglycemia (11.0%), hypertension (30.0%) and obesity (16.0%). The majority of the individuals, during the interview did not report the diseases detected by the testes. The results revealed that the high prevalence of hypercholesterolemia, hypertriglyceridemia, obesity, hypertension and diabetes mellitus could be consequence of the delayed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hyperlipidemia; Hyperglycemia; Hypertension; Obesity; Coronary heart disease - Paraná State - Brazil. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000300008 |
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| Zubioli,Arnaldo; Silva,Maria Angélica Rafaini Covas Pereira da; Tasca,Raquel Soares; Curi,Rui; Bazotte,Roberto Barbosa. |
| This study develops and evaluates a pharmaceutical consultation program (PCP) to improve treatment for Type 2 diabetes patients (T2DP) and reduce risk factors for diabetic complications with possible application in other chronic diseases. We recruited T2DP receiving conventional medical treatment but with fasting glycemia >140mg/dl and/or glycated hemoglobin >7%. The PCP includes strategies obtained from Dader's method, the PWDT (Pharmacist's Workup of Drug Therapy method) model of pharmaceutical care, the SOAP (Subjective data, Objective data, Assessment, and Plan of care) method, and concepts based on a nursing care model. The PCP evaluated lifestyle, pharmacotherapy and monitoring it using laboratory tests, vital signs, and anthropometry.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pharmaceutical care; Type 2 diabetes/treatment; Type 2 diabetes/pharmaceutical care; Pharmaceutical consultation; Glycated hemoglobin; Diabetes education; Pharmacy. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100010 |
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