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| Curtis, C.F.. |
| The idea of genetic control of insect pests and vectors was invented independently three times in the 1930s-40s. Results with releases of radiation-sterilized male tsetse have been encouraging. Much work was done in the 1970s on mosquitoes with sterile males and systems that could potentially be used for gene driving. Chemosterilized Anopheles separated from females by a genetic sexing system was successfully released in El Salvador. In India chemosterilization, cytoplasmic incompatibility, translocations and meiotic drive were tested with culicine mosquitoes in field cages, for mating competitiveness in the field and in some cases in village-wide release trials. However, a town-wide eradication attempt with Aedes aegypti was stopped due to spurious claims... |
| Tipo: Conference proceedings |
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| Ano: 2005 |
URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1183 |
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| Curtis, C.F.. |
| The transgenic RIDL method could ensure that male mosquitos can be released without biting females and that the males would have no female progeny after mating to wild females. Urban Anopheles or Aedes vector populations, surrounded by different species in rural areas, would seem to be the most appropriate targets for such releases, aiming at eradication. In urban areas intensity of transmission is generally not very high and the public-health outcomes of such urban programmes could be monitored by passive surveillance through health facilities or by active surveillance for infections with or without associated symptoms. The alternative use of transgenic mosquitos would be to produce strains refractory to infection by pathogens such as Plasmodium and to... |
| Tipo: Conference proceedings |
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| Ano: 2004 |
URL: http://library.wur.nl/ojs/index.php/frontis/article/view/852 |
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| Curtis, C.F.. |
| A genetic driving system extremely closely genetically linked to a refractoriness gene is needed if such genes are to be of any use in the control of vector-borne disease. Wolbachia cytoplasmic symbionts and/or appropriate factors from Wolbachia incorporated into the mosquito genome may be usable as driving factors. Maximal fitness of refractoriness factors is needed, otherwise any genetic recombination between the refractoriness factor and the driver can be shown, by simple models, to lead ultimately to fixation of the driver no longer linked to the refractoriness factor. Models can also show the serious impact of non-isolation of the target wild population and incompleteness of the refractoriness |
| Tipo: Conference proceedings |
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| Ano: 2005 |
URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1199 |
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| Mnzava, A.; Curtis, C.F.; Manga, L.; Touré, Y.T.. |
| Advances in transgenic technology have allowed the development of genetically transformed insects that have reduced ability to support the development of disease pathogens. The integration of this new method within national vector control programmes is indeed the biggest challenge, notwithstanding the current weak health systems in most disease-endemic countries (DECs) to efficiently apply vector control interventions. Moreover, where integration is considered, it is essential that reliable data are available on the multiple effects of the interventions. This should be done in parallel to the general strengthening of both human, technical, financial and physical resources at all levels of the national health system |
| Tipo: Conference proceedings |
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| Ano: 2005 |
URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1201 |
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