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| Almeida,Igor Vivian de; Domingues,Giovana; Soares,Lilian Capelari; Düsman,Elisângela; Vicentini,Veronica Elisa Pimenta. |
| Flunitrazepam (FNZ) is a sedative benzodiazepine prescribed for the short-term treatment of insomnia. However, there are concerns regarding possible carcinogenic or genotoxic effects of this medicine. Thus, the aim of this study was to evaluate the cytotoxic, clastogenic and aneugenic effects of FNZ in hepatoma cells from Rattus norvegicus (HTC) in vitro and in bone marrow cells of Wistar rats in vivo. These effects were examined in vitro following treatment with 0.2, 1.0, 5.0 or 10 μg/mL FNZ using a micronucleus test with a cytokinesis block or in vivo using a chromosomal aberration test following treatment with 7, 15 or 30 μg/mL/kg body weight. The results showed that the benzodiazepine concentrations tested were not cytotoxic, aneugenic or clastogenic.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Flunitrazepam/cytotoxic effects; Flunitrazepam/clastogenic effects; Flunitrazepam/aneugenic effects; Sedative benzodiazepine/adverse effects/in vitro and in vivo study; Chromosomal abnormalities/medicines effects. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200251 |
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| Düsman,Elisângela; Ferreira,Márcia Flores da Silva; Berti,Alessandra Paim; Mariucci,Rosinete Gonçalves; Mantovani,Mário Sérgio; Vicentini,Veronica Elisa Pimenta. |
| Fruits are important sources of nutrients in human diet, and Barbados Cherry (Malpighia glabra L.) is of particular interest due to its high content of antioxidants. Diets rich in fruits and vegetables protect individuals against diseases and cancer, but excessive intake of vitamins may act as pro-oxidant and generate changes in DNA. To evaluate the effect of different in natura (BAN) and frozen (BAF) Barbados Cherry pulp concentrations and synthetic vitamin C in liquid form (VC) on the chromosome level and the cell cycle division, root meristeme cells of Allium cepa L. and bone marrow cells of Wistar rats Rattus norvegicus, were used as test system. In Allium cepa L., BAN, at the highest concentration (0.4 mg.mL-1) and BAF, at the lowest concentration... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antioxidants; Cytotoxicity; Mutagenesis. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612012000200030 |
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