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| GUIMARÃES,CARINE A.; BIELLA,MAIRIS S.; LOPES,ABIGAIL; DEROZA,PEDRO F.; OLIVEIRA,MARIANA B.; MACAN,TAMIRES P.; STRECK,EMILIO L.; FERREIRA,GUSTAVO C.; ZUGNO,ALEXANDRA I.; SCHUCK,PATRÍCIA F.. |
| Increased fructose concentrations are the biochemical hallmark of fructosemia, a group of inherited disorders on the metabolic pathway of this sugar. The main clinical findings observed in patients affected by fructosemia include neurological abnormalities with developmental delay, whose pathophysiology is still undefined. In the present work we investigated the in vitro and in vivo effects of fructose on acetylcholinesterase (AchE) activity in brain structures of developing rats. For the in vitro experiments, fructose was added at increasing concentrations to the incubation medium. It was observed that fructose provoked an inhibition of acetylcholinesterase activity in cerebral cortex of 30-day-old-rats, even at low concentrations (0.1 mM). For the in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acetylcholinesterase; Brain; Fructosel hereditary fructose intolerance. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401919 |
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