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Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats Anais da ABC (AABC)
GAVRILOVIĆ,LJUBICA; STOJILJKOVIĆ,VESNA; KASAPOVIĆ,JELENA; POPOVIĆ,NATAŠA; PAJOVIĆ,SNEŽANA B.; DRONJAK,SLADJANA.
ABSTRACTChronic isolation of adult animals represents a form of psychological stress that produces sympatho-adrenomedullar activation. Exercise training acts as an important modulator of sympatho-adrenomedullary system. This study aimed to investigate physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase, dopamine-ß-hydroxylase and phenylethanolamine N-methyltransferase) and cyclic adenosine monophosphate response element-binding (CREB) in the adrenal medulla, concentrations of catecholamines and corticosterone (CORT) in the plasma and the weight of adrenal glands of chronically psychosocially stressed adult rats exposed daily to 20 min treadmill running for 12 weeks. Also, we examined how...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adrenal medulla; Acute immobilization stress; Catecholamine; Chronic social isolation; Gene expression; Treadmill exercise.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000300999
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Differential regulation of catecholamine synthesis and transport in rat adrenal medulla by fluoxetine treatment Anais da ABC (AABC)
SPASOJEVIC,NATASA; JOVANOVIC,PREDRAG; DRONJAK,SLADJANA.
We have recently shown that chronic fluoxetine treatment acted significantly increasing plasma norepinephrine and epinephrine concentrations both in control and chronically stressed adult male rats. However, possible effects of fluoxetine on catecholamine synthesis and re-uptake in adrenal medulla have been largely unknown. In the present study the effects of chronic fluoxetine treatment on tyrosine hydroxylase, a rate-limiting enzyme in catecholamine synthesis, as well as a norepinephrine transporter and vesicular monoamine transporter 2 gene expressions in adrenal medulla of animals exposed to chronic unpredictable mild stress (CUMS) for 4 weeks, were investigated. Gene expression analyses were performed using a real-time quantitative reverse...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adrenal medulla; Antidepressant; Gene expression; Norepinephrine transporter; Tyrosine hydroxylase.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100343
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