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	Provedor de dados BABT (1) Autor Dalmarco,Eduardo Monguilhott (1) Fröde,Tânia Silvia (1) Palavra-chave CD11a/CD18 adhesion molecules (1) Leukocyte migration (1) Methotrexate (1) Mice (1) Pleurisy (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2007 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Methotrexate inhibits integrin adhesion molecules in the mouse model of pleurisy induced by carrageenan BABT Dalmarco,Eduardo Monguilhott; Fröde,Tânia Silvia. The aim of this work was to analyze the effect of methotrexate (MTX) upon leukocyte migration and expression of adhesion molecules CD11a/CD18 in the lung, 4 and 48 h after inflammation induction by carrageenan in mice. The results showed that MTX significantly decreased leukocyte influx and CD11a expression in the lung at 4 and 48 h of pleurisy (P < 0.01). MTX also inhibited CD18 expression at 4 h but not 48 h of pleurisy (P < 0.01). These results proved that MTX at the studied doses had important anti-inflammatory properties, acting primarily on leukocyte migration from the pleural cavity to the lung via inhibition of CD11a/CD18 expression in the mouse model of inflammation. Tipo: Info:eu-repo/semantics/article Palavras-chave: Methotrexate; CD11a/CD18 adhesion molecules; Leukocyte migration; Pleurisy; Mice. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000500005 Registros recuperados: 1 Primeira ... 1 ... Última

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