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Reactome: A database of biological pathways Nature Precedings
David Croft.
REACTOME is an open-source, open access, manually curated, peer-reviewed and highly reliable pathway database. A new website is currently in preparation, which includes tools for visualising pathway diagrams and analyzing user-supplied data in a pathway context. Reactome provides facilities for exporting its content in BioPax and SBML formats.
Tipo: Presentation Palavras-chave: Bioinformatics.
Ano: 2010 URL: http://precedings.nature.com/documents/5025/version/1
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Reactome - a knowledgebase of human biological pathways Nature Precedings
Bijay Jassal; Esther E. Schmidt; Guanming Wu; Imre Vastrik; David Croft; Bernard de Bono; Gopal Gopinath; Marc Gillespie; Steven Jupe; Gavin O'Kelly; Lisa Matthews; Phani V. Garapati; Michael Caudy; Alexander Kanapin; Bruce May; Shahana Mahajan; Ewan Birney; Peter D'Eustachio; Lincoln Stein.
Reactome ("http://www.reactome.org":http://www.reactome.org) is an expert-authored, peer-reviewed knowledgebase of human reactions and pathways that functions as a data mining resource and electronic textbook. Its current release includes 2921 human proteins, 2871 reactions and 4167 literature citations. This curated dataset is integrated with a functional interaction network assembled computationally from non-curated sources of information including protein-protein interactions, gene co-expression, and gene ontology annotations, providing access. A new entity-level pathway viewer and improved search and data mining tools facilitate searching and visualizing pathway data and the analysis of user-supplied high-throughput data...
Tipo: Poster Palavras-chave: Chemistry; Genetics & Genomics; Immunology; Molecular Cell Biology; Bioinformatics.
Ano: 2009 URL: http://precedings.nature.com/documents/3200/version/1
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BioPax and SBML output from Reactome: where we are, where we are heading Nature Precedings
David Croft.
Reactome is a free, open-source, open access, pathway database. Currently, Reactome has over 5000 human proteins, involved in over 4000 manually curated reactions. Additionally, it has nearly 30,000 reactions inferred by orthology projection from human to 20 other model organisms. Facilities exist for exporting single pathways or the entire database to either BioPax or SBML. SBML generation now uses libSBML, ensuring syntactic correctness, and has adopted MIRIAM URIs for references to external databases. For the future, we anticipate that users will be able to submit a list of species to Reactome and obtain as an output customized BioPax or SBML, based on reactions extracted from Reactome.
Tipo: Presentation Palavras-chave: Bioinformatics; Data Standards.
Ano: 2011 URL: http://precedings.nature.com/documents/6376/version/1
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Reactome - a knowledgebase of human biological pathways Nature Precedings
Peter D'Eustachio; David Croft; Bernard de Bono; Gopal Gopinath; Marc Gillespie; Bijay Jassal; Lisa Matthews; Esther Schmidt; Imre Vastrik; Guanming Wu; Suzanna Lewis; Ewan Birney; Lincoln Stein.
Pathway curation is a powerful tool for systematically associating gene products with functions. Reactome (www.reactome.org) is a manually curated human pathway knowledgebase describing a wide range of biological processes in a computationally accessible manner. The core unit of the Reactome data model is the Reaction, whose instances form a network of biological interactions through entities that are consumed, produced, or act as catalysts. Entities are distinguished by their molecular identities and cellular locations. Set objects allow grouping of related entities. Curation is based on communication between expert authors and staff curators, facilitated by freely available data entry tools. Manually curated data are subjected to quality control and peer...
Tipo: Poster Palavras-chave: Molecular Cell Biology; Bioinformatics.
Ano: 2007 URL: http://precedings.nature.com/documents/1281/version/1
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