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	Provedor de dados Nature Precedings (1) Autor David Westaway (1) Gerold Schmitt-Ulms (1) Holger Wille (1) Joel C. Watts (1) Sepehr Ehsani (1) Palavra-chave Evolutionary Biology (1) Genetics & Genomics (1) Molecular Cell Biology (1) Tipo do documento Manuscript (1) Ano 2009 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Evolutionary descent of prion genes from a ZIP metal ion transport ancestor Nature Precedings Gerold Schmitt-Ulms; Sepehr Ehsani; Joel C. Watts; David Westaway; Holger Wille. In the more than 20 years since its discovery, both the phylogenetic origin and cellular function of the prion protein (PrP) have remained enigmatic. Insights into the function of PrP may be obtained through a characterization of its molecular neighborhood. Quantitative interactome data revealed the spatial proximity of a subset of metal ion transporters of the ZIP family to mammalian prion proteins. A subsequent bioinformatic analysis revealed the presence of a prion-like protein sequence within the N-terminal, extracellular domain of a phylogenetic branch of ZIPs. Additional structural threading and ortholog sequence alignment analyses consolidated the conclusion that the prion protein gene family is phylogenetically derived from a ZIP-like ancestor... Tipo: Manuscript Palavras-chave: Genetics & Genomics; Molecular Cell Biology; Evolutionary Biology. Ano: 2009 URL: http://precedings.nature.com/documents/2867/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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