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	Provedor de dados BJMBR (5) Autor Defino,H.L.A. (5) da-Silva,C.A. (2) Bel,E. Del (1) Bel,E.A.Del (1) Borges,C.A.G. (1) Castania,M. (1) Castania,V. (1) Del Bel,E.A. (1) Del-Bel,E.A. (1) Facincani,I. (1) Giglio,C.A. (1) Guimarães,F.S. (1) Issy,A.C. (1) Jorgetti,V. (1) Mattar,R. (1) Nogueira-Barbosa,M.H. (1) Paula,F.J.A. de (1) Pereira,F.A. (1) Ramalho,L.N.Z. (1) Salmon,C.E.G. (1) Mais... Palavra-chave Spinal cord injury (3) Animal models (2) Area postrema (1) Biomechanics (1) Dorsal horn (1) Experimental models (1) Fos immunohistochemistry (1) Functional recovery (1) Growth factors (1) Hepatic osteodystrophy (1) Histology (1) Intermediolateral column neurons (1) Intervertebral disc degeneration (1) Laminectomy (1) Melatonin (1) Motor performance test (1) Osteoporosis pathogenesis (1) Pamidronate (1) Reticular formation (1) Sensorial test (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Info:eu-repo/semantics/other (1) Ano 2013 (2) 2012 (1) 2006 (1) 2000 (1) País Brazil (5) Idioma Inglês (5)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última Effect of melatonin on the functional recovery from experimental traumatic compression of the spinal cord BJMBR Schiaveto-de-Souza,A.; da-Silva,C.A.; Defino,H.L.A.; Bel,E.A.Del. Spinal cord injury is an extremely severe condition with no available effective therapies. We examined the effect of melatonin on traumatic compression of the spinal cord. Sixty male adult Wistar rats were divided into three groups: sham-operated animals and animals with 35 and 50% spinal cord compression with a polycarbonate rod spacer. Each group was divided into two subgroups, each receiving an injection of vehicle or melatonin (2.5 mg/kg, intraperitoneal) 5 min prior to and 1, 2, 3, and 4 h after injury. Functional recovery was monitored weekly by the open-field test, the Basso, Beattie and Bresnahan locomotor scale and the inclined plane test. Histological changes of the spinal cord were examined 35 days after injury. Motor scores were progressively... Tipo: Info:eu-repo/semantics/article Palavras-chave: Spinal cord injury; Melatonin; Functional recovery. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400348 Induction of Fos protein immunoreactivity by spinal cord contusion BJMBR Del-Bel,E.A.; Borges,C.A.G.; Defino,H.L.A.; Guimarães,F.S.. The objective of the present study was to identify neurons in the central nervous system that respond to spinal contusion injury in the rat by monitoring the expression of the nuclear protein encoded by the c-fos gene, an activity-dependent gene, in spinal cord and brainstem regions. Rats were anesthetized with urethane and the injury was produced by dropping a 5-g weight from 20.0 cm onto the exposed dura at the T10-L1 vertebral level (contusion group). The spinal cord was exposed but not lesioned in anesthetized control animals (laminectomy group); intact animals were also subjected to anesthesia (intact control). Behavioral alterations were analyzed by Tarlov/Bohlman scores, 2 h after the procedures and the animals were then perfused for... Tipo: Info:eu-repo/semantics/other Palavras-chave: Fos immunohistochemistry; Intermediolateral column neurons; Reticular formation; Area postrema; Dorsal horn; Solitary tract nuclei; Laminectomy; Spinal cord injury. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000500006 Behavioral and physiological methods for early quantitative assessment of spinal cord injury and prognosis in rats BJMBR Giglio,C.A.; Defino,H.L.A.; da-Silva,C.A.; de-Souza,A.S.; Del Bel,E.A.. Methods for reliable evaluation of spinal cord (SC) injury in rats at short periods (2 and 24 h) after lesion were tested to characterize the mechanisms implicated in primary SC damage. We measured the physiological changes occurring after several procedures for producing SC injury, with particular emphasis on sensorimotor functions. Segmental and suprasegmental reflexes were tested in 39 male Wistar rats weighing 250-300 g divided into three control groups that were subjected to a) anesthesia, b) dissection of soft prevertebral tissue, and c) laminectomy of the vertebral segments between T10 and L1. In the lesion group the SC was completely transected, hemisected or subjected to vertebral compression. All animals were evaluated 2 and 24 h after the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trauma; Spinal cord injury; Experimental models; Sensorial test; Motor performance test. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001200013 Pamidronate for the treatment of osteoporosis secondary to chronic cholestatic liver disease in Wistar rats BJMBR Pereira,F.A.; Mattar,R.; Facincani,I.; Defino,H.L.A.; Ramalho,L.N.Z.; Jorgetti,V.; Volpon,J.B.; Paula,F.J.A. de. Osteoporosis is a major complication of chronic cholestatic liver disease (CCLD). We evaluated the efficacy of using disodium pamidronate (1.0 mg/kg body weight) for the prevention (Pr) or treatment (Tr) of cholestasis-induced osteoporosis in male Wistar rats: sham-operated (Sham = 12); bile duct-ligated (Bi = 15); bile duct-ligated animals previously treated with pamidronate before and 1 month after surgery (Pr = 9); bile duct-ligated animals treated with pamidronate 1 month after surgery (Tr = 9). Rats were sacrificed 8 weeks after surgery. Immunohistochemical expression of IGF-I and GH receptor was determined in the proximal growth plate cartilage of the left tibia. Histomorphometric analysis was performed in the right tibia and the right femur was used... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatic osteodystrophy; Osteoporosis pathogenesis; Growth factors; Biomechanics; Animal models; Pamidronate. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200021 Experimental model of intervertebral disc degeneration by needle puncture in Wistar rats BJMBR Issy,A.C.; Castania,V.; Castania,M.; Salmon,C.E.G.; Nogueira-Barbosa,M.H.; Bel,E. Del; Defino,H.L.A.. Animal models of intervertebral disc degeneration play an important role in clarifying the physiopathological mechanisms and testing novel therapeutic strategies. The objective of the present study is to describe a simple animal model of disc degeneration involving Wistar rats to be used for research studies. Disc degeneration was confirmed and classified by radiography, magnetic resonance and histological evaluation. Adult male Wistar rats were anesthetized and submitted to percutaneous disc puncture with a 20-gauge needle on levels 6-7 and 8-9 of the coccygeal vertebrae. The needle was inserted into the discs guided by fluoroscopy and its tip was positioned crossing the nucleus pulposus up to the contralateral annulus fibrosus, rotated 360° twice, and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Intervertebral disc degeneration; Animal models; Histology; Wistar rats. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300235 Registros recuperados: 5 Primeira ... 1 ... Última

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