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Vancomycin: the need to suit serum concentrations in hemodialysis patients BJID
Marengo,Lívia Luize; Del Fiol,Fernando de Sá; Oliveira,Sara de Jesus; Nakagawa,Celso; Croco,Eduardo Leite; Barberato-Filho,Silvio; Peçanha,Marcela Pellegrini; Silva,Douglas Felix da; Toledo,Maria Inês de.
The vancomycin dose for hemodialysis (HD) patients should be adjusted by monitoring drug serum concentrations. However, this procedure is not available in most health services in Brazil, which usually adopts protocols based on published studies. The trials available are controversial, and several have not been conducted with current dialyzers. This study aimed at assessing the suitability of vancomycin serum concentrations in HD patients at a public hospital. Blood samples of HD patients were collected from November 2006 to May 2007, at time intervals of 48, 96, 120, or 168 hours after vancomycin administration. Drug measurement was performed with polarized light immunofluorescence. Approximately 86% of trough vancomycin serum concentrations were below the...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Vancomycin; Chronic renal failure; Hemodialysis.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200019
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Evaluation of the prescription and use of antibiotics in Brazilian children BJID
Del Fiol,Fernando de Sá; Lopes,Luciane Cruz; Barberato-Filho,Silvio; Motta,Cristiane de Cássia Bergamaschi.
INTRODUCTION: Inappropriate use of antibiotics leads to increased levels of bacterial resistance making it difficult to treat upper respiratory tract infections. The appropriate use of these drugs has a fundamental role in controlling resistance and in success of treatment of childhood infections. Therefore, the aim of this study was to assess the prescription and use of antibiotics for Brazilian children. METHODS: The use of antibiotics in 160 children was monitored in two Primary Health Centers by questionnaires administered to parents and caregivers that assessed the social, demographic and clinical conditions of the children. Furthermore, the antibiotic use pattern was ascertained in these children and compared to the recommendations of the Brazilian...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibiotic Pediatrics Prescription.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300005
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