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	Provedor de dados BJPS (2) Autor Dinakaran,Sathis Kumar (2) Avasarala,Harani (1) Banji,David (1) Harani,Avasarala (1) Killi,Gnana Deepika (1) Kumar,Santhos (1) Maddinapudi,Rama Krishna (1) Rao,Venkateshwar (1) Mais... Palavra-chave Bi-layer tablet (1) Bulk drugs/impurity profile (1) Bulk drugs/qualitative analysis (1) Lopinavir/determination (1) Pharmaceutical formulations/impurity profile (1) Pharmaceutical formulations/qualitative analysis (1) Ritonavir/determination (1) Sustained release (1) Trihexyphenidyl HCl (1) Ultra Performance liquid chromatography/qualitative analysis (1) Ultra Performance liquid chromatography/quantitative analysis (1) Ziprasidone HCl (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Formulation and evaluation of bi-layer floating tablets of ziprasidone HCl and trihexyphenidyl HCl BJPS Dinakaran,Sathis Kumar; Kumar,Santhos; Banji,David; Avasarala,Harani; Rao,Venkateshwar. The purpose of this research study was to establish ziprasidone HCl NR 40 mg and trihexyphenidyl HCl SR 4mg in the form of bi-layer sustained release floating tablets. The tablets were prepared using sodium HPMC K4M / HPMC K15M as bio-adhesive polymers and sodium bicarbonate acting as a floating layer. Tablets were evaluated based on different parameters such as thickness, hardness, friability, weight variation, in vitro dissolution studies, content of active ingredient and IR studies. The physico-chemical properties of the finished product complied with the specifications. In vitro release from the formulation was studied as per the USP XXIII dissolution procedure. The formulations gave a normal release effect followed by sustained release for 12 h which... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bi-layer tablet; Ziprasidone HCl; Trihexyphenidyl HCl; Sustained release. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300012 A novel validated UPLC method for quantitation of lopinavir and ritonavir in bulk drug and pharmaceutical formulation with its impurities BJPS Killi,Gnana Deepika; Maddinapudi,Rama Krishna; Dinakaran,Sathis Kumar; Harani,Avasarala. A simple gradient Ultra Performance liquid chromatographic method (UPLC) was developed for determination of lopinavir and ritonavir from its related impurities and assay for the first time. This method involves the use of a C18 (Acquity UPLC BEH C18, 50 × 2.1 mm, 1.7 µm) column thermostated at 30 oC using triethylamine (pH 2.2): 0.1% H3PO4 in acetonitrile and methanol (85:15) as mobile phase in gradient elution mode. A Photo Diode Array (PDA) detector set at 215 nm was used for detection with flow rate 0.4 mL/min. This method was validated over the range of limit of quantitation (LOQ) to 50 to 150% of impurity specification limit and of working concentration for assay. The developed method was validated for linearity, range, precision, accuracy and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Lopinavir/determination; Ritonavir/determination; Ultra Performance liquid chromatography/qualitative analysis; Ultra Performance liquid chromatography/quantitative analysis; Bulk drugs/qualitative analysis; Pharmaceutical formulations/qualitative analysis; Pharmaceutical formulations/impurity profile; Bulk drugs/impurity profile. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200301 Registros recuperados: 2 Primeira ... 1 ... Última

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