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Pancrace, Claire; Ishida, Keishi; Briand, Enora; Pichi, Douglas Gatte; Weiz, Annika R.; Guljarnow, Arthur; Scalvenzi, Thibault; Sassoon, Nathalie; Hertweck, Christian; Dittmann, Elke; Gugger, Muriel. |
The cyanobacterial genus Microcystis is known to produce an elaborate array of structurally unique and biologically active natural products, including hazardous cyanotoxins. Cytotoxic aeruginoguanidines represent a yet unexplored family of peptides featuring a trisubstituted benzene unit and farnesylated arginine derivatives. In this study, we aimed at assigning these compounds to a biosynthetic gene cluster by utilizing biosynthetic attributes deduced from public genomes of Microcystis and the sporadic distribution of the metabolite in axenic strains of the Pasteur Culture Collection of Cyanobacteria. By integrating genome mining with untargeted metabolomics using liquid chromatography with mass spectrometry, we linked aeruginoguanidine (AGD) to a... |
Tipo: Text |
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Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00481/59277/62216.pdf |
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Georges Des Aulnois, Maxime; Réveillon, Damien; Robert, Elise; Caruana, Amandine; Briand, Enora; Guljamow, Arthur; Dittmann, Elke; Amzil, Zouher; Bormans, Myriam. |
The transfer of Microcystis aeruginosa from freshwater to estuaries has been described worldwide and salinity is reported as the main factor controlling the expansion of M. aeruginosa to coastal environments. Analyzing the expression levels of targeted genes and employing both targeted and non-targeted metabolomic approaches, this study investigated the e ect of a sudden salt increase on the physiological and metabolic responses of two toxic M. aeruginosa strains separately isolated from fresh and brackish waters, respectively, PCC 7820 and 7806. Supported by di erences in gene expressions and metabolic profiles, salt tolerance was found to be strain specific. An increase in salinity decreased the growth of M. aeruginosa with a lesser impact on the... |
Tipo: Text |
Palavras-chave: Microcystis aeruginosa; Microcystin; Salt stress; Metabolomic; Transcript. |
Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00615/72689/71692.pdf |
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