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	Provedor de dados BJMBR (2) Autor Dogini,D.B. (2) Lopes-Cendes,I. (2) Gilioli,R. (1) Lopes-Ramos,C.M. (1) Pereira,T.C. (1) Vieira,A.S. (1) Mais... Palavra-chave Coenzyme Q10 (1) Drug treatment (1) Gene regulation (1) Lithium carbonate (1) Machado-Joseph disease (1) MicroRNA (1) Molecular biomarkers (1) Spinocerebellar ataxia type 3 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2016 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Role of non-coding RNAs in non-aging-related neurological disorders BJMBR Vieira,A.S.; Dogini,D.B.; Lopes-Cendes,I.. Protein coding sequences represent only 2% of the human genome. Recent advances have demonstrated that a significant portion of the genome is actively transcribed as non-coding RNA molecules. These non-coding RNAs are emerging as key players in the regulation of biological processes, and act as "fine-tuners" of gene expression. Neurological disorders are caused by a wide range of genetic mutations, epigenetic and environmental factors, and the exact pathophysiology of many of these conditions is still unknown. It is currently recognized that dysregulations in the expression of non-coding RNAs are present in many neurological disorders and may be relevant in the mechanisms leading to disease. In addition, circulating non-coding RNAs are emerging as... Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNA; Gene regulation; Molecular biomarkers. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000800301 Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease BJMBR Lopes-Ramos,C.M.; Pereira,T.C.; Dogini,D.B.; Gilioli,R.; Lopes-Cendes,I.. Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by expansion of the polyglutamine domain of the ataxin-3 (ATX3) protein. MJD/SCA3 is the most frequent autosomal dominant ataxia in many countries. The mechanism underlying MJD/SCA3 is thought to be mainly related to protein misfolding and aggregation leading to neuronal dysfunction followed by cell death. Currently, there are no effective treatments for patients with MJD/SCA3. Here, we report on the potential use of lithium carbonate and coenzyme Q10 to reduce cell death caused by the expanded ATX3 in cell culture. Cell viability and apoptosis were evaluated by MTT assay and by flow cytometry after staining with annexin... Tipo: Info:eu-repo/semantics/article Palavras-chave: Machado-Joseph disease; Spinocerebellar ataxia type 3; Lithium carbonate; Coenzyme Q10; Drug treatment. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001200601 Registros recuperados: 2 Primeira ... 1 ... Última

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