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	Provedor de dados BJPS (1) Autor Bhattacharyya,Dibya Ranjan (1) Chetia,Dipak (1) Dohutia,Chandrajit (1) Gogoi,Kabita (1) Sarma,Kishore (1) Palavra-chave ADME/Tox. (1) Curcumin/Knoevenagel condensates (1) Curcumin/antimalarial activity (1) Curcumin/synthesis (1) Docking (1) In vitro (1) Malaria (1) PfATP6 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Molecular docking, synthesis and in vitro antimalarial evaluation of certain novel curcumin analogues BJPS Dohutia,Chandrajit; Chetia,Dipak; Gogoi,Kabita; Bhattacharyya,Dibya Ranjan; Sarma,Kishore. ABSTRACT The receptor protein PfATP6 has been identified as the common target of artemisinin and curcumin. The work was initiated to assess the antimalarial activity of six curcumin derivatives based on their binding affinities and correlating the in silico docking outcome with in vitro antimalarial screening results. A ligand library of thirty two Knoevenagel condensates of curcumin were designed and docked against PfATP6 protein and six compounds with the best binding scores were synthesized and screened for their antimalarial activity against the sensitive 3D7 strain of Plasmodium falciparum. ADME/Tox, pharmacokinetic and pharmacodynamic profiles of the designed compounds were analyzed and reported. 4-FB was found to have similar binding energy to the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Curcumin/synthesis; Curcumin/antimalarial activity; Curcumin/Knoevenagel condensates; PfATP6; Malaria; Docking; In vitro; ADME/Tox.. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400603 Registros recuperados: 1 Primeira ... 1 ... Última

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