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Freitas,Karine M. de; Almeida,Jacqueline M.; Monteiro,Juliana C.; Diamante,Maria Aparecida S.; Vale,Jéssica S.F. do; Camargo,Camila; Jorge,Marçal H.A.; Dolder,Heidi. |
Cyclosporin A (CsA) is a widely employed immunosuppressive drug that is associated with several side effects, among then hepatotoxicity. Heteropterys tomentosais a Brazilian plant efficient in reducing damage caused by CsA on the rat testis and prostate. The aim of this study was to evaluate the effect of CsA and H. tomentosa(administered isolated or simultaneously) on the liver of Wistar rats. The animals were treated daily with water (control), CsA (15mg/kg/day), H. tomentosainfusion or CsA+H. tomentosa, for 21 or 56 days. The treatments did not alter liver morphology or cause fibrosis. H. tomentosaadministered for 21 days increased the number of hepatocyte nuclei and Kupffer cell volumetric proportion. After 56 days of treatment, H.... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatotoxicity; Heteropterys aphrodisiaca; Medicinal plant; Phytotherapy; Hepatotoxicidade; Heteropterys aphro disiaca; Planta medicinal; Fitoterapia. |
Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100369 |
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Mancini,Karina; Dolder,Heidi. |
This study was undertaken to detect protein components in both sperm types of the butterfly Euptoieta hegesia. These spermatozoa possess complex extracellular structures for which the composition and functional significance are still unclear. In the apyrene sperm head, the proteic cap presented an external ring and an internal dense content; basic proteins were detected only in external portions. In the tail, the paracrystalline core of mitochondrial derivatives and the axoneme are rich in proteins. The extratesticular spermatozoa are covered by a proteic coat, which presented two distinct layers. In eupyrene spermatozoa, acrosome and nucleus were negatively stained, probably because of their high compaction. In the tail, there is no paracrystalline core... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ultrastructure; Protein; Apyrene; Eupyrene. |
Ano: 2004 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452004000300006 |
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Ferreira,Adelina; Dolder,Heidi. |
Spermatogenesis, with emphasis on spermiogenesis, is described for the lizard, Tropidurus itambere, using light microscopy, phase contrast and epifluorescence, as well as scanning and transmission electron microscopy. Cellular differentiation involves events of chromatin condensation, nuclear elongation and the formation of structural complexes, such as the acrosomal and axonemal ones. Other new characteristics, exclusive for this species, include various aspects of the subacrosomal granule, the insertion of the pro-acrosomal vesicle and the development of these structures to participate in the acrosomal complex. Radial projections occur just above the nuclear shoulders, which have been recognized already from the beginning of cellular elongation. The... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ultrastructure; Sperm; Spermatogenesis; Lizard; Tropiduridae. |
Ano: 2003 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452003000300006 |
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Freitas,Karine Moura de; Natali,Antônio José; Lunz,Wellington; Costa,Kyvia Lugate Cardoso; Leite,Rodrigo Paula; Dolder,Heidi; Matta,Sérgio Luis Pinto da. |
This study was undertaken to determine whether colon cancer (CC) and chronic swimming exercise alter rat testis. Eleven weeks old rats were distributed into control group (n=6) and the groups that were induced to develop CC by dimethylhydrazine injections (nEG, EG0, EG2 and EG4; n=10 each group). In the group nEG, the rats did not swim, whereas groups EG0, EG2 and EG4, underwent a swimming program with distinct loads (0, 2 and 4% of body mass, respectively) for 35 weeks. The morphometry, stereology and cell counts showed damage caused by the CC on the germ epithelium. These results were noteworthy since this was the first report to associate the CC with testicular damage. Swimming exercise had no significant role in reducing, or increasing the CC effects... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 1; 2-dimethylhydrazine fertility reproduction spermatogenesis. |
Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000400005 |
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