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Therapeutic effects of compound hypertonic saline on rats with sepsis BJID
Dong,Fang; Chen,Wei; Xu,Liang; Wang,Huabing; Lu,Huizhi.
Sepsis is one of the major causes of death and is the biggest obstacle preventing improvement of the success rate in curing critical illnesses. Currently, isotonic solutions are used in fluid resuscitation technique. Several studies have shown that hypertonic saline applied in hemorrhagic shock can rapidly increase the plasma osmotic pressure, facilitate the rapid return of interstitial fluid into the blood vessels, and restore the effective circulating blood volume. Here, we established a rat model of sepsis by using the cecal ligation and puncture approach. We found that intravenous injection of hypertonic saline dextran (7.5% NaCl/6% dextran) after cecal ligation and puncture can improve circulatory failure at the onset of sepsis. We found that the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sepsis; Cecal ligation and puncture; Immune regulation; Lung injury.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500518
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