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| Castro,Paula Ferreira; Ribeiro,Eliane; Dorea,Egidio Lima; Pinto,Gelba Almeida; Hirata,Rosario Dominguez Crespo. |
| ABSTRACT Statins are the most prescribed lowering-cholesterol drugs. They are well tolerated, however, some patients present muscular adverse symptoms. Clinical and laboratory data from 120 dyslipidemic patients prescribed with statins were obtained from January to December/2013 at a University Hospital in Sao Paulo city, Brazil, to study factors associated with statin-related adverse muscular events (AME). Pharmacotherapy and statin-related AME data (serum CK elevation and any degree of myopathy, myalgia, myositis or rhabdomyolysis) of the dyslipidemic patients were recorded. The study was approved by local Ethics Committees. Simvastatin (70%) and atorvastatin (25%) were the most prescribed statins. AME related to statin treatment were found in 17% of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Statins/study/effects; Statins/ muscular adverse event; Dyslipidemia; Drug intolerance; Drug interaction/pharmacotherapy. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400618 |
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| Martins,Vanessa dos Santos; Mori,Ana Luiza Pereira Moreira; Dorea,Egidio Lima; Pinto,Gelba Almeida; Hirata,Mario Hiroyuki; Hirata,Felipe Dominguez Crespo; Hirata,Rosario Dominguez Crespo. |
| ABSTRACT Management of pharmacotherapy in elderly with metabolic diseases is challenging and potentially inappropriate medications (PIMs) are risk factors for drug interactions and adverse events. The exposure to PIMs in elderly outpatients with metabolic diseases and its relationship with polypharmacy and other variables was investigated. PIMs prescribed to 207 elderly patients (aged 60 to 96 years) with metabolic diseases who attended a University Hospital of Sao Paulo city, Brazil, from April/2010 to January/2011, were evaluated. PIMs were detected using both 2003 Beers and 2008 STOPP criteria. The association between PIMs and age, gender and polypharmacy was also examined. 2008 STOPP criteria detected more PIMs (44.4 %) than 2003 Beers criteria (16.0%,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Potentially inappropriate medications/elderly/effects; Elderly/metabolic diseases/study; Pharmacotherapy/elderly; Beers criteria; STOPP criteria; Polypharmacy.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400699 |
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