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	Provedor de dados BJMBR (4) Autor Duarte,M.E.L. (4) Fonseca,E.C. (2) Aguiar,D.P. (1) Andrade,C.V. (1) Andress,D.L. (1) Balduino,A. (1) Barbosa,A.P.F. (1) Carvalho,E.F. (1) Cruz,E.A.S. (1) Fernandes,M.B.C. (1) Lopez,P.M. (1) Lucena,S.B.G. (1) Mello,M.A. (1) Moura Neto,V. (1) Silva,J.D.P. (1) Torres,E.S. (1) de Sousa,E.B. (1) dos Santos Junior,G.C. (1) Mais... Palavra-chave Apoptosis (1) Chondrocytes (1) Chronic renal failure (1) Corticosteroids (1) Cytokines (1) Dialysis (1) Growth hormone (1) Growth plate (1) Growth retardation (1) Insulin (1) Insulin-like growth factor I (1) Metabolomics (1) Micromass cultures (1) NMR (1) Osteitis fibrosa (1) Osteoarthritis (1) Renal failure (1) Renal osteodystrophy (1) Secondary hyperparathyroidism (1) Synovial Fluid (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2017 (1) 2007 (1) 2003 (1) 2002 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Cytokine accumulation in osteitis fibrosa of renal osteodystrophy BJMBR Duarte,M.E.L.; Carvalho,E.F.; Cruz,E.A.S.; Lucena,S.B.G.; Andress,D.L.. Bone marrow fibrosis occurs in association with a number of pathological states. Despite the extensive fibrosis that sometimes characterizes renal osteodystrophy, little is known about the factors that contribute to marrow accumulation of fibrous tissue. Because circulating cytokines are elevated in uremia, possibly in response to elevated parathyroid hormone levels, we have examined bone biopsies from 21 patients with end-stage renal disease and secondary hyperparathyroidism. Bone sections were stained with antibodies to human interleukin-1alpha (IL-1alpha), IL-6, IL-11, tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-ß (TGF-ß) using an undecalcified plastic embedding method. Intense staining for IL-1alpha, IL-6, TNF-alpha and TGF-ß... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytokines; Osteitis fibrosa; Renal osteodystrophy; Chronic renal failure; Dialysis; Secondary hyperparathyroidism. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100004 Insulin impairs the maturation of chondrocytes in vitro BJMBR Torres,E.S.; Andrade,C.V.; Fonseca,E.C.; Mello,M.A.; Duarte,M.E.L.. The precise nature of hormones and growth factors directly responsible for cartilage maturation is still largely unclear. Since longitudinal bone growth occurs through endochondral bone formation, excess or deficiency of most hormones and growth factors strongly influences final adult height. The structure and composition of the cartilaginous extracellular matrix have a critical role in regulating the behavior of growth plate chondrocytes. Therefore, the maintenance of the three-dimensional cell-matrix interaction is necessary to study the influence of individual signaling molecules on chondrogenesis, cartilage maturation and calcification. To investigate the effects of insulin on both proliferation and induction of hypertrophy in chondrocytes in vitro we... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chondrocytes; Insulin; Micromass cultures; Apoptosis. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900007 Metabolomics as a promising tool for early osteoarthritis diagnosis BJMBR de Sousa,E.B.; dos Santos Junior,G.C.; Duarte,M.E.L.; Moura Neto,V.; Aguiar,D.P.. Osteoarthritis (OA) is the main cause of disability worldwide, due to progressive articular cartilage loss and degeneration. According to recent research, OA is more than just a degenerative disease due to some metabolic components associated to its pathogenesis. However, no biomarker has been identified to detect this disease at early stages or to track its development. Metabolomics is an emerging field and has the potential to detect many metabolites in a single spectrum using high resolution nuclear magnetic resonance (NMR) techniques or mass spectrometry (MS). NMR is a reproducible and reliable non-destructive analytical method. On the other hand, MS has a lower detection limit and is more destructive, but it is more sensitive. NMR and MS are useful... Tipo: Info:eu-repo/semantics/article Palavras-chave: NMR; Metabolomics; Osteoarthritis; Synovial Fluid. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100301 Response of the growth plate of uremic rats to human growth hormone and corticosteroids BJMBR Barbosa,A.P.F.; Silva,J.D.P.; Fonseca,E.C.; Lopez,P.M.; Fernandes,M.B.C.; Balduino,A.; Duarte,M.E.L.. Children with chronic renal failure in general present growth retardation that is aggravated by corticosteroids. We describe here the effects of methylprednisolone (MP) and recombinant human growth hormone (rhGH) on the growth plate (GP) of uremic rats. Uremia was induced by subtotal nephrectomy in 30-day-old rats, followed by 20 IU kg-1 day-1 rhGH (N = 7) or 3 mg kg-1 day-1 MP (N = 7) or 20 IU kg-1 day-1 rhGH + 3 mg kg-1 day-1 MP (N = 7) treatment for 10 days. Control rats with intact renal function were sham-operated and treated with 3 mg kg-1 day-1 MP (N = 7) or vehicle (N = 7). Uremic rats (N = 7) were used as untreated control animals. Structural alterations in the GP and the expression of anti-proliferating cell nuclear antigen (PCNA) and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Corticosteroids; Growth hormone; Renal failure; Growth retardation; Growth plate; Insulin-like growth factor I. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800011 Registros recuperados: 4 Primeira ... 1 ... Última

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