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	Provedor de dados 52 (2) Autor Boschi,Alessandra (2) Duatti,Adriano (2) Uccelli,Licia (2) Pasquali,Micol (1) Palavra-chave Brain imaging (1) Nitrido Complexes (1) Nitrido complexes (1) Technetium-99m (1) Technetium-99m Radiopharmaceuticals (1) Tipo do documento Info:eu-repo/semantics/article (2) Ano 2007 (1) 2002 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Technetium-99m nitrido radiopharmaceuticals with unprecedented biological properties 52 Duatti,Adriano; Boschi,Alessandra; Uccelli,Licia. The chemical methods for the production of technetium-99m radiopharmaceuticals containing a terminal Tc<FONT FACE=Symbol>º</FONT>N triple bond have been established more than a decade ago. From that time, the chemistry of nitrido Tc-99m complexes has provided a highly efficient tool for the design and preparation of novel classes of diagnostic agents, and a number of potentially useful radiopharmaceuticals have been discovered. In particular, nitrido technetium-99m tracers have been developed for heart perfusion imaging. In this short review, the chemical and biological properties of the neutral myocardial perfusion tracer bis(N-ethoxy, N-ethyl-dithiocarbamato) nitrido Tc-99m (TcN-NOEt) will be summarized along with the preparation and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Technetium-99m Radiopharmaceuticals; Nitrido Complexes. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500019 Novel Tc-99m radiotracers for brain imaging 52 Boschi,Alessandra; Pasquali,Micol; Uccelli,Licia; Duatti,Adriano. A novel class of Tc-99m complexes able to cross the blood brain barrier has been investigated and described here. These compounds are formed by reacting the bis-substituted nitrido precusors [99mTc(N)(PS)2] (PS = phosphino-thiol ligand) with triethylborane (BEt3) under strictly anhydrous conditions and using non-aqueous solvents. The molecular structure of these tracers was not fully established, but preliminary experimental evidence suggests that they result from the interaction of the Lewis base [99mTc(N)(PS)2] with the Lewis acid BEt3, which leads to the formation of the novel -B-N<FONT FACE=Symbol>º</FONT> Tc- adduct. After purification and recovery in a physiological solution, the new borane-nitrido Tc-99m derivatives were injected in rats... Tipo: Info:eu-repo/semantics/article Palavras-chave: Brain imaging; Nitrido complexes; Technetium-99m. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600005 Registros recuperados: 2 Primeira ... 1 ... Última

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