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| Chennoufi, Rahima; Bougherara, Houcine; Gagey-eilstein, Nathalie; Dumat, Blaise; Henry, Etienne; Subra, Frederic; Bury-mone, Stephanie; Mahuteau-betzer, Florence; Tauc, Patrick; Teulade-fichou, Marie-paule; Deprez, Eric. |
| Photodynamic therapy (PDT) leads to cell death by using a combination of a photosensitizer and an external light source for the production of lethal doses of reactive oxygen species (ROS). Since a major limitation of PDT is the poor penetration of UV-visible light in tissues, there is a strong need for organic compounds whose activation is compatible with near-infrared excitation. Triphenylamines (TPAs) are fluorescent compounds, recently shown to efficiently trigger cell death upon visible light irradiation (458 nm), however outside the so-called optical/therapeutic window. Here, we report that TPAs target cytosolic organelles of living cells, mainly mitochondria, triggering a fast apoptosis upon two-photon excitation, thanks to their large two-photon... |
| Tipo: Text |
Palavras-chave: Apoptosis; Small molecules. |
| Ano: 2016 |
URL: http://archimer.ifremer.fr/doc/00320/43168/42726.pdf |
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