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High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile Biol. Res.
GUZMAN,LEDA M; KORIYAMA,CHIHAYA; AKIBA,SUMINORI; EIZURU,YOSHITO; CASTILLO,DARWINS; CORVALAN,ALEJANDRO; AGUAYO,FRANCISCO R.
The inactivation of tumour suppressor genes by aberrant methylation of promoter regions has been described as a frequent event in neoplasia development, including lung cancer. The p16 gene is a tumour suppressor gene involved in the regulation of cell cycle progression that has been reported to be inactivated by promoter methylation in lung carcinomas at variable frequencies around the world in a smoking habit dependent manner. The purpose of this study was to investigate the methylation status of the promoter region of the p16 gene in 74 non-small cell lung carcinomas from Chile. The frequency of p16 gene inactivation by promoter methylation was determined as 79.7% (59/74). When we considered histological type, we observed that p16 promoter methylation...
Tipo: Journal article Palavras-chave: Lung carcinoma; Methylation; Promoter region.
Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000400011
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