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| Samuel Bogoch; Elenore S. Bogoch. |
| Advance warning of pathogen outbreaks has not been possible heretofore. A new class of genomic peptides associated with rapid replication was discovered and named replikins. Software was designed to analyze replikins quantitatively. Replikin concentration changes were measured annually prior to, and “real time” every few days during, the 2009 H1N1 influenza pandemic. Replikins were seen by both linear sequence representation and three-dimensional X-ray diffraction, and found to expand on the virus hemagglutinin surface prior to and during the H1N1 pandemic.

A highly significant increased concentration of virus replikins was found a) retrospectively in three pandemics from 1918 to 1999 (14,227... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Genetics & Genomics; Immunology; Microbiology; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6279/version/1 |
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| Samuel Bogoch; Elenore S. Bogoch. |
| Earlier studies have shown that the increased concentration of a new class of virus genomic peptides, Replikins, precedes and predicts virus outbreaks. We now find that the area in the genome of the highest concentration of Replikins, and the country in which this peak exists in scout viruses, have permitted in the past five years seven consecutive accurate predictions of the geographic localization of coming outbreaks, including those now realized in Mexico for H1N1, and in Cambodia for H5N1. Real-time Replikin analysis of the evolution of the virus genome identified both mutations and structural reorganization of the hemagglutinin and p B1 genes over several years before each outbreak. This information, together with the specific Replikin sequences so... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Genetics & Genomics; Microbiology; Bioinformatics. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6952/version/1 |
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| Samuel Bogoch; Elenore S. Bogoch. |
| The genomes of all groups of viruses whose sequences are listed on Pubmed, specimens since 1918, analyzed by a software from Bioradar UK Ltd., contain Replikins which range in concentration from a Replikin Count (number of Replikins per 100 amino acids) of less than 1 to 30 (see accompanying communications for higher Counts in tuberculosis, malaria, and cancer, associated with higher lethality). Counts of less than 4.0 were found in ‘resting’ virus states; Counts greater than 4.0, found to be associated with rapid replication, were found invariably to accompany or to predict virus outbreaks, by as much as two years, in viral hosts examined from salmon, to birds, to livestock, to humans. X-ray diffraction showed Replikins to be on the... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Chemistry; Genetics & Genomics; Immunology; Microbiology; Bioinformatics. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/7144/version/1 |
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